Short Communication
British Journal of Cancer (2008) 99, 1246–1250. doi:10.1038/sj.bjc.6604692 www.bjcancer.com
Published online 30 September 2008
Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
O Treeck1,2, C Lattrich1,2, I Juhasz-Boess1, S Buchholz1, G Pfeiler1 and O Ortmann1
1Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Strasse 65, Regensburg 93053, Germany
Correspondence: Dr O Treeck, E-mail: otreeck@caritasstjosef.de
2These authors contributed equally to this work.
Revised 29 August 2008; Accepted 2 September 2008; Published online 30 September 2008.
Abstract
Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ER
2, ER5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.
Keywords:
adiponectin, mammary epithelial cell, breast cancer cell line, gene regulation
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