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British Journal of Cancer (2008) 98, 1431-1433.
doi:10.1038/sj.bjc.6604258 www.bjcancer.com Published online 18 March 2008
Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
M Szybka1, I Zawlik2, D Kulczycka1, E Golanska2, E Jesien1,3, D Kupnicka1, R Stawski2, S Piaskowski2, E Bieniek2, M Zakrzewska2, R Kordek1, P P Liberski2 and P Rieske2
1Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland
2Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka 8/10, Lodz 92-216, Poland
3Department of Radiology, Medical University of Lodz, Czechoslowacka 8/10, Lodz 92-216, Poland
Correspondence to: Dr P Rieske, E-mail: piotrrieske@yahoo.com
Received 13 August 2007; revised 18 December 2007; accepted 18 January 2008; published online 18 March 2008
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
Keywords: P53; glioblastoma; methylation; mRNA
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