Genetics and Genomics

British Journal of Cancer (2008) 98, 1431–1433. doi:10.1038/sj.bjc.6604258 www.bjcancer.com
Published online 18 March 2008

Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

M Szybka1, I Zawlik2, D Kulczycka1, E Golanska2, E Jesien1,3, D Kupnicka1, R Stawski2, S Piaskowski2, E Bieniek2, M Zakrzewska2, R Kordek1, P P Liberski2 and P Rieske2

  1. 1Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland
  2. 2Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka 8/10, Lodz 92-216, Poland
  3. 3Department of Radiology, Medical University of Lodz, Czechoslowacka 8/10, Lodz 92-216, Poland

Correspondence: Dr P Rieske, E-mail: piotrrieske@yahoo.com

Received 13 August 2007; Revised 18 December 2007; Accepted 18 January 2008; Published online 18 March 2008.

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Abstract

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.

Keywords:

P53, glioblastoma, methylation, mRNA