Short Communication

British Journal of Cancer (2008) 98, 1820–1823. doi:10.1038/sj.bjc.6604380 www.bjcancer.com
Published online 27 May 2008

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

A M J Langers1, C F M Sier1, L J A C Hawinkels1, F J G M Kubben1, W van Duijn1, J J van der Reijden1, C B H W Lamers1, D W Hommes1 and H W Verspaget1

1Department of Gastroenterology–Hepatology, Leiden University Medical Centre, Leiden, The Netherlands

Correspondence: Dr CFM Sier, Department of Gastroenterology–Hepatology, Leiden University Medical Centre, PO Box 9600, Leiden 2300 RC, The Netherlands. E-mail: c.f.m.sier@lumc.nl

Received 4 February 2008; Revised 8 April 2008; Accepted 8 April 2008.

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Abstract

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2-1306T and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9-1562C>T was not. Tumour MMP levels were not determined by their SNP genotypes.

Keywords:

metalloproteinase, SNP, survival, prognosis