Molecular Diagnostics
British Journal of Cancer (2008) 98, 1641–1645. doi:10.1038/sj.bjc.6604365 www.bjcancer.com
Published online 13 May 2008
SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue
S Kennedy1, M Clynes2, P Doolan2, J P Mehta2, S Rani2, J Crown1,2 and L O'Driscoll2
- 1St Vincent's University Hospital, Dublin 4, Ireland
- 2National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
Correspondence: Dr L O'Driscoll, E-mail: Lorraine.ODriscoll@dcu.ie
Received 13 March 2008; Revised 28 March 2008; Accepted 3 April 2008; Published online 13 May 2008.
Abstract
The prevalence and clinical relevance of SNIP/p140Cap has not been extensively investigated. Here SNIP/p140Cap mRNA expression was studied in 103 breast tumour biopsies, where it was detected in 
37% of tumour specimens, but not in any normal breast specimens. Expression correlated significantly with unfavourable overall survival. This suggests that SNIP/p140Cap may be a useful diagnostic and prognostic marker for breast cancer and its expression in breast cancer, but not in normal breast tissue, suggests that it may have potential as a therapeutic target.
Keywords:
breast cancer, SNIP, disease/relapse-free survival, overall survival, quantitative reverse-transcriptase polymerase chain reaction (qPCR)
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