Epidemiology

British Journal of Cancer (2007) 97, 995–998. doi:10.1038/sj.bjc.6603933 www.bjcancer.com
Published online 2 October 2007

Diabetes and endometrial cancer: effect modification by body weight, physical activity and hypertension

E Lucenteforte1, C Bosetti1, R Talamini2, M Montella3, A Zucchetto2, C Pelucchi1, S Franceschi4, E Negri1, F Levi5 and C La Vecchia1,6

  1. 1Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy
  2. 2Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy
  3. 3Unità di Epidemiologia, Istituto Nazionale Tumori 'Fondazione Giovanni Pascale', Naples, Italy
  4. 4International Agency for Research on Cancer, Lyon Cedex, France
  5. 5Unité d'épidémiologie du cancer, Institut de Médicine sociale et préventive (IUMSP), Université de Lausanne, Switzerland
  6. 6Istituto di Statistica Medica e Biometria 'G. A. Maccacaro', Università degli Studi di Milano, Milan, Italy

Correspondence: Dr E Lucenteforte, Istituto di Ricerche Farmacologiche 'Mario Negri', Via La Masa 19 – 20156 Milan, Italy. E-mail: lucenteforte@marionegri.it

Received 11 June 2007; Revised 12 July 2007; Accepted 23 July 2007.

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Abstract

Among 777 endometrial cancer cases and 1550 controls from Italy and Switzerland, odds ratio was 1.7 (95% confidence interval: 1.2–2.5) for diabetes, and 5.1 for obese diabetic women as compared with non-obese non-diabetic ones. Diabetes shows a supramultiplicative effect with body mass index, but not with physical activity or hypertension.

Keywords:

case–control study, endometrial cancer, diabetes, body mass index, physical activity, hypertension