TABLE 1

FROM:

The GRAIDS Trial: a cluster randomised controlled trial of computer decision support for the management of familial cancer risk in primary care

J Emery, H Morris, R Goodchild, T Fanshawe, A T Prevost, M Bobrow and A L Kinmonth

Table 1. Eastern Region Familial Breast/Ovarian and Colorectal Cancer Guidelines

Breast/ovarian cancer
High risk criteria:
1.	Two relatives who are FDR of each other with breast cancer where average age of diagnosis is under 40 years.
2.	Three or more relatives who are FDR of each other with ovarian or breast cancer, where average age of diagnosis is under 60 years
3.	Four or more relatives who are FDR of each other with breast or ovarian cancer at any age
4.	One individual in family with breast and ovarian cancer
Moderate risk:
1.	One female FDR with breast cancer <40 years
2.	One paternal female SDR with breast cancer <40 years
3.	One female FDR with bilateral breast cancer <60 years
4.	Two FDR/SDR with breast cancer <60 years or ovarian cancer any age
5.	Three FDR/SDR with breast or ovarian cancer any age
6.	One male FDR with breast cancer any age
Colorectal cancer
1.	One affected FDR <45 years
2.	One affected FDR and 1 affected SDR on same side of family
3.	Two FDR (inc both parents)
4.	Three affected relatives any age
'Affected' means diagnosed with either of the following:
a.	CRC, colorectal cancer: 3 adenomatous polyps, one adenomatous polyp <60 years.
b.	HRC, HNPCC-related cancer: endometrium, ovary, gastric, small bowel, ureter, renal pelvis
There should be at least one CRC in the family.

 Abbreviations: CRC, colorectal cancer; FDR, first-degree relative; HRC, HNPCC-related cancer; SDR=second-degree relative.