FIGURES AND TABLES
FROM:
NK-cell and T-cell functions in patients with breast cancer: effects of surgery and adjuvant chemo- and radiotherapy
F Mozaffari, C Lindemalm, A Choudhury, H Granstam-Björneklett, I Helander, M Lekander, E Mikaelsson, B Nilsson, M-L Ojutkangas, A Österborg, L Bergkvist and H Mellstedt
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Figure 1.
Absolute number of CD161+NK cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. The box represents the 25th to 75th percentiles. The line in the middle of the box represents the median. The top whisker is drawn from the value associated with the 75th to the 90th percentile, the bottom one associated with the 25th to the 10th percentile. The outliers show the highest and lowest 10% of observed values. * P< 0.05, ** P< 0.01 and *** P< 0.001.
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Figure 2.
Absolute number of NKB1+NK cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. For symbols see Figure 1.
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Figure 3.
Flow cytometric analysis of CD4+CD25high and CD4+CD25+ T cells in healthy donors and breast cancer patients. A minimum of 20 000 events in the lymphocyte gate was calculated during acquisition and the analyses was performed on all events calculated. Numbers in the plot indicate the percentage of cells within the respective rectangle.
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Figure 4.
Absolute number of CD25high expressing CD8 T cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. For symbols see Figure 1.
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Figure 5.
Absolute number of CD28 expressing CD4 T cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. For symbols see Figure 1.
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Figure 6.
Absolute number of Zap70 expressing CD4 T cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT)(n=21) treated breast cancer patients. For symbols see Figure 1.
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Figure 7.
CD3
(A) and Zap70 (B) expressing (MFI) CD8 T cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. For symbols see Figure 1.
Figure 8.
Percentage of IFN-
-producing T cells in normal control donors (C) (n=11), Pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT) (n=21) treated breast cancer patients. (A) CD4; (B) CD8 T cells. For symbols see Figure 1.
Figure 9.
Percentage of IL-4 (A) and IL-2 (B) producing CD4 T cells in normal control donors (C) (n=11), pretreatment (PT) (n=9), post-treatment radiation (RT) (n=20) and post-treatment radiation/chemotherapy (RT+CT)(n=21) treated breast cancer patients. For symbols see Figure 1.
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