Epidemiology
British Journal of Cancer (2007) 96, 1127–1134. doi:10.1038/sj.bjc.6603649 www.bjcancer.com
Published online 3 April 2007
Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review
S A Raza1,2, G M Clifford2 and S Franceschi2
- 1Department of Surgery, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
- 2International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France
Correspondence: Dr S Franceschi, E-mail: franceschi@iarc.fr
Received 29 November 2006; Revised 24 January 2007; Accepted 29 January 2007.
Abstract
We combined information published worldwide on the seroprevalence of hepatitis B surface antigen (HbsAg) and antibodies against hepatitis C virus (anti-HCV) in 27 881 hepatocellular carcinomas (HCCs) from 90 studies. A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt. Anti-HCV was found more often than HBsAg in Europe and the United States.
Keywords:
hepatitis B virus, hepatitis C virus, hepatocellular carcinoma, meta-analysis
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