Epidemiology
British Journal of Cancer (2006) 95, 1277–1279. doi:10.1038/sj.bjc.6603442 www.bjcancer.com
Published online 24 October 2006
Long-term aspirin use and colorectal cancer risk: a cohort study in Sweden
S C Larsson1, E Giovannucci2,3 and A Wolk1
- 1Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- 2Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
- 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Correspondence: Dr SC Larsson, E-mail: susanna.larsson@ki.se
Received 31 August 2006; Revised 25 September 2006; Accepted 27 September 2006; Published online 24 October 2006.
Abstract
In a prospective cohort study of 74 250 Swedish women and men, with 7.2 years of follow-up and 705 incident colorectal cancer cases, long duration of aspirin use (>20 years) was associated with a reduced risk of colorectal cancer (multivariate rate ratio: 0.65; 95% confidence interval: 0.45–0.94). Aspirin use for a shorter period was not associated with risk.
Keywords:
aspirin, cohort studies, colorectal cancer, nonsteroidal anti-inflammatory drugs, prospective studies
