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British Journal of Cancer (2006) 95, 639-641.
doi:10.1038/sj.bjc.6603309 Published online 8 August 2006
CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea
J Gwack1, A Shin2, C-S Kim1, K-P Ko1, Y Kim1, J K Jun1, J Bae1, S K Park1, Y-C Hong1, D Kang1, S-H Chang3, H-R Shin4 and K-Y Yoo1,5
1Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea
2Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, USA
3Department of Preventive Medicine, Konkuk University College of Medicine, 322 Danwol-dong, Chungju-si, Chungcheongbuk-do 380-701, Korea
4Research Institute for National Cancer Control and Evaluation, National Cancer Center, 809 Madu1-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Korea
5National Cancer Center, 809 Madu1-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Korea
Correspondence to: Dr K-Y Yoo, Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea. E-mail: kyyoo@plaza.snu.ac.kr
Received 1 June 2006; revised 30 June 2006; accepted 10 July 2006; published online 8 August 2006
In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).
Keywords: gastric cancer; Helicobacter pylori; CagA; Cohort study; Korea
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