BJC Open article

British Journal of Cancer (2006) 94, 1342–1347. doi:10.1038/sj.bjc.6603111 www.bjcancer.com
Published online 18 April 2006

Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates

A-S Evrard1,2, D Hémon1,2, A Morin3, D Laurier4, M Tirmarche4, J-C Backe3, M Chartier3 and J Clavel1,2

  1. 1INSERM, U754, Villejuif, France
  2. 2Université Paris Sud, IFR69, Villejuif, France
  3. 3Institut de Radioprotection et de Sûreté Nucléaire, IRSN/DRPH/SER/UETP, Fontenay-aux-Roses, France
  4. 4Institut de Radioprotection et de Sûreté Nucléaire, IRSN/DRPH/SRBE/LEPID, Fontenay-aux-Roses, France

Correspondence: Dr J Clavel, INSERM-U754, 16, avenue Paul Vaillant-Couturier, Villejuif cedex 94807, France. E-mail: clavel@vjf.inserm.fr

Received 11 January 2006; Revised 20 March 2006; Accepted 27 March 2006
Advance online publication 18 April 2006



The present study investigated for the first time the incidence of childhood leukaemia (1990–2001) around French nuclear installations using a geographic zoning based on estimated doses to the red bone marrow due to gaseous radioactive discharges. The observed number of cases of acute leukaemia (O=750) in 40km2 centred on 23 French nuclear installations between 1990 and 2001 was lower than expected (E=795.01), although not significantly so (standardised incidence ratio SIR=0.94, 95% confidence interval=(0.88–1.01)). In none of the five zones defined on the basis of the estimated doses was the SIR significantly >1. There was no evidence of a trend in SIR with the estimated doses for all the children or for any of the three age groups studied. This study confirmed that there was no evidence of an increased incidence of childhood leukaemia around the 23 French nuclear sites.


childhood leukaemia; nuclear sites; incidence; estimated dose



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