|
|
British Journal of Cancer (2006) 94, 781-784.
doi:10.1038/sj.bjc.6603034 Published online 7 March 2006
The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer
G W A Lamb1, D C McMillan2, S Ramsey1 and M Aitchison1
1Department of Urology, Gartnavel General Hospital, Glasgow G12 0YN, UK
2University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
Correspondence to: Dr DC McMillan, E-mail: d.c.mcmillan@clinmed.gla.ac.uk
Received 5 December 2005; revised 6 February 2006; accepted 7 February 2006; published online 7 March 2006
The relationship between tumour stage, grade (Fuhrman), performance status (ECOG), a combined score (UCLA Integrated Staging System, UISS), systemic inflammatory response (elevated C-reactive protein concentration), and cancer-specific survival was examined in patients undergoing potentially curative resection for renal clear cell cancer (n=100). On univariate survival analysis, sex (P=0.050), tumour stage (P=0.001), Fuhrman grade (P<0.001), UISS (P<0.001), C-reactive protein (P=0.002) were significant predictors of survival. On multivariate analysis with sex, UISS and C-reactive protein entered as covariates, only UISS (HR 2.70, 95% CI 1.00-7.30, P=0.050) and C-reactive protein (HR 4.00, 95% CI 1.21-13.31, P=0.024) were significant independent predictors of survival. The presence of a preoperative systemic inflammatory response predicts poor cancer-specific survival in patients who have undergone potentially curative resection for renal clear cell cancer.
Keywords: renal cancer; nephrectomy; tumour stage; grade; performance status; systemic inflammatory response; cancer-specific survival
back to top  |
| Article links | |
| ||
| ||
 | Send to a friend | |
 | Download PDF | |
| ||
| ||
| ||
 | Full text | |
| ||
| ||
| ||
 | Preceding article | |
 | Next article | |
 | Table of Contents | |
| ||
| ||
| ||
| ||
| ||
|
|
|
|
| |||
| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
| |||
| Privacy Policy | |||