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British Journal of Cancer (2006) 94, 776-780.
doi:10.1038/sj.bjc.6603023 Published online 21 February 2006
MicroRNAs in cell proliferation, cell death, and tumorigenesis
H-W Hwang1 and J T Mendell1
1Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 460C, Baltimore, MD 21205, USA
Correspondence to: Dr JT Mendell, E-mail: jmendell@jhmi.edu
Received 22 November 2005; revised 30 January 2006; accepted 31 January 2006; published online 21 February 2006
MicroRNAs (miRNAs) are a recently discovered class of ~18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
Keywords: microRNAs; cellular proliferation; apoptosis; oncogene; tumour suppressor
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
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