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British Journal of Cancer (2006) 94, 771-775.
doi:10.1038/sj.bjc.6603019 Published online 28 February 2006
Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE
P Hasson1 and Z Paroush2
1Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
2Department of Biochemistry, Faculty of Medicine, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
Correspondence to: Dr P Hasson, E-mails: phasson@nimr.mrc.ac.uk or Dr Z Paroush, zparoush@cc.huji.ac.il
Received 27 September 2005; revised 30 January 2006; accepted 30 January 2006; published online 28 February 2006
In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.
Keywords: EGFR; Groucho/TLE; Notch; signal transduction; transcriptional regulation
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
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