Minireview
British Journal of Cancer (2006) 94, 620–624. doi:10.1038/sj.bjc.6602994 www.bjcancer.com
Published online 21 February 2006
Tumours and tremors: how PTEN regulation underlies both
- 1Campbell Family Institute for Breast Cancer Research, Toronto, Ontario M5G 2C1, Canada
- 2Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada
- 3Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
Correspondence: Dr TW Mak, Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada; E-mail: tmak@uhnres.utoronto.ca
Received 6 October 2005; Revised 23 January 2006; Accepted 23 January 2006; Published online 21 February 2006.
Abstract
Mutations of the tumour suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are seen in many human cancers. However, dysregulation of PTEN may be involved in other disease states such as Parkinson's disease. This minireview describes recent work examining PTEN regulation and its implications for the development of both cancer and neurodegenerative disease.
Keywords:
PTEN, DJ-1, tumour suppression, Parkinson's disease
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