British Journal of Cancer

TABLE 2

FROM:

Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?

L Arnould, M Gelly, F Penault-Llorca, L Benoit, F Bonnetain, C Migeon, V Cabaret, V Fermeaux, P Bertheau, J Garnier, J-F Jeannin and B Coudert

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Table 2. Immune cell infiltration into breast tumours following PST

Figure and tables index
  TAXHER01 (n=23) Control (n=46) D (n=23) NT–NT (n=23) TAXHER01 vs control D vs NT–NT
Antibodies location Mean (s.d.) staining intensity score P-value
CD20
 Diffuse1.61 (1.3)1.10 (0.9)1.09 (0.9)1.04 (0.9)0.08020.8272
 Around1.13 (1.5)0.52 (1.2)0.39 (1.0)0.65 (1.3)0.05980.4432
 Inside0.43 (0.9)0.33 (0.9)0.04 (0.1)0.61 (1.2)0.40130.0686
 Foci3.13 (1.2)1.70 (1.5)1.61 (1.4)1.78 (1.7) 0.0005 0.8391
       
CD3
 Diffuse2.09 (1.4)1.42 (1.0)1.35 (0.9)1.50 (1.1) 0.0386 0.7389
 Around1.52 (1.6)0.82 (1.5)0.70 (1.4)0.95 (1.5)0.05600.5014
 Inside0.65 (1.2)0.47 (1.0)0.39 (0.9)0.55 (1.1)0.47340.5014
 Foci2.87 (1.1)1.64 (1.2)1.43 (1.1)1.86 (1.4) 0.0001 0.2116
       
CD4
 Diffuse1.04 (1.3)0.91 (0.9)0.91 (0.8)0.91 (0.9)0.76050.8776
 Around1.35 (1.7)0.46 (1.0)0.39 (1.0)0.52 (1.1) 0.0270 0.5223
 Inside0.35 (0.7)0.04 (0.2)0.00 (0.0)0.09 (0.3) 0.0209 0.1527
 Foci2.17 (1.3)1.30 (1.3)1.65 (1.2)0.96 (1.3) 0.0107 0.0627
       
CD8
 Diffuse1.96 (1.5)1.87 (0.9)1.96 (0.9)1.78 (1.0)0.56700.4738
 Around1.56 (1.7)0.76 (1.4)0.52 (1.2)1.00 (1.5) 0.0460 0.1997
 Inside1.22 (1.3)0.78 (1.1)0.65 (1.1)0.91 (1.0)0.19990.2454
 Foci2.39 (1.6)1.50 (1.4)1.43 (1.3)1.56 (1.5) 0.0160 0.6410
       
CD68
 Diffuse1.91 (1.3)2.30 (1.2)2.43 (1.2)2.17 (1.2)0.30360.5172
 Around0.91 (1.6)0.54 (1.3)0.48 (1.3)0.61 (1.3)0.35940.5271
 Inside0.56 (1.0)0.39 (0.8)0.26 (0.7)0.52 (0.8)0.56760.1883
 Foci0.09 (0.4)0.00 (0.0)0.00 (0.0)0.00 (0.0)0.1573 
       
PS100
 Diffuse1.70 (1.3)1.59 (1.2)1.48 (0.9)1.70 (1.5)0.70680.9540
 Around1.35 (1.6)0.63 (1.3)0.30 (0.9)0.96 (1.5) 0.0557 0.1234
 Inside0.61 (1.3)0.37 (0.9)0.13 (0.6)0.61 (1.1)0.4579 0.0488
 Foci1.74 (1.7)1.1 (1.4)0.78 (1.2)1.35 (1.6) 0.0691 0.2202
       
CD1a
 Diffuse1.61 (0.8)1.83 (0.9)1.74 (0.8)1.91 (0.9)0.37880.4385
 Around0.39 (0.7)0.41 (1.0)0.39 (1.0)0.43 (1.0)0.55560.5378
 Inside0.26 (0.5)0.28 (0.9)0.17 (0.7)0.39 (1.0)0.31800.5968
 Foci0.00 (0.0)0.00 (0.0)0.00 (0.0)0.00 (0.0)  
       
HLA-DR
 Diffuse2.09 (1.0)2.33 (1.0)2.26 (0.8)2.39 (1.1)0.53700.4624
 Around1.70 (1.7)1.04 (1.5)0.83 (1.5)1.26 (1.5)0.11510.2308
 Inside0.91 (1.2)0.72 (1.0)0.39 (0.8)1.04 (1.1)0.5778 0.0258
 Foci2.30 (1.1)1.54 (1.3)1.70 (1.3)1.39 (1.3) 0.0335 0.4649
       
CD56 a
 Diffuse0.83 (1.0)0.74 (0.8)0.87 (0.8)0.61 (0.8)1.00000.2125
 Around1.00 (1.5)0.57 (1.1)0.43 (1.0)0.70 (1.2)0.2468a 0.3175
 Inside0.30 (0.7)0.11 (0.4)0.09 (0.4)0.13 (0.3)0.2520a 0.3336
 Foci0.26 (0.7)0.28 (0.8)0.26 (0.9)0.30 (0.7)0.97390.4756
       
NK1
 Diffuse1.45 (1.4)1.20 (0.9)1.39 (0.8)1.00 (0.9)0.58640.1349
 Around1.64 (1.6)0.41 (1.0)0.43 (1.1)0.39 (1.0) 0.0003 0.7919
 Inside0.82 (1.3)0.30 (0.8)0.17 (0.7)0.43 (1.0) 0.0438 0.2251
 Foci2.01 (1.4)0.74 (1.1)0.83 (1.1)0.65 (1.1) 0.0003 0.4678
       
TiA1
 Diffuse1.13 (1.3)1.30 (1.0)1.30 (0.9)1.30 (1.1)0.44110.9816
 Around1.43 (1.7)0.85 (1.5)0.61 (1.4)1.1 (1.6)0.19820.3113
 Inside0.65 (1.0)0.26 (0.8)0.17 (0.7)0.35 (0.9) 0.0370 0.3878
 Foci1.00 (1.0)0.54 (1.0)0.65 (1.2)0.43 (0.8)0.21810.5759
       
Granzyme B
 Diffuse0.26 (0.7)0.26 (0.4)0.30 (0.5)0.22 (0.4)0.48700.5066
 Around0.83 (1.3)0.28 (0.9)0.22 (0.9)0.35 (0.9) 0.0324 0.4087
 Inside0.22 (0.7)0.07 (0.3)0.13 (0.5)0.00 (0.0)0.19260.1528
 Foci0.52 (0.8)0.33 (0.7)0.13 (0.3)0.52 (0.9)0.25710.1126

 NT–NT, anthracycline-based PST that does not include a taxane or trastuzumab; D, docetaxel-based PST.

 For diffuse/around/inside/foci, scores range from 0 to 4.

a Staining with CD56 was less intense and difficult to quantify.

 Significant if P<0.05. Bold values signify their importance in the results and the discussion.

Figure and tables index
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