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British Journal of Cancer (2006) 94, 1678-1682.
doi:10.1038/sj.bjc.6603180 Published online 23 May 2006
Increased expression of pAKT is associated with radiation resistance in cervical cancer
T-J Kim1,3, J-W Lee1,3, S Y Song2, J-J Choi1, C H Choi1, B-G Kim1, J-H Lee1 and D-S Bae1
1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Gangnam-gu, Seoul 135-710, Korea
2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Gangnam-gu, Seoul 135-710, Korea
Correspondence to: Dr D-S Bae, E-mail: ds123.bae@samsung.com
3These authors contributed equally to this work.
Received 9 January 2006; revised 12 April 2006; accepted 25 April 2006; published online 23 May 2006
Phosphorylated AKT (pAKT) is a major contributor to radioresistance in human cancers. The aim of this study was to investigate the association of pAKT expression and radiation resistance in cervical cancer. A retrospective review was made of the records of 27 women who received primary radiation therapy due to locally advanced cervical cancer (LACC) with FIGO stage IIB-IVA. Nine patients regarded as radiation resistant developed local recurrences with a median progression free interval of 9 months. Eighteen patients did not show local recurrences, and were regarded as a radiation-sensitive group. Using pretreatment paraffin-embedded tissues, we evaluated pAKT expression by immunohistochemistry. A significant association was found between the level of pAKT expression and local recurrence. Immunohistochemical staining for pAKT was significantly more frequent in the radiation-resistant than in the radiation-sensitive group (P=0.004). The mean progression-free survival was 86 months for patients with pAKT-negative staining (19 cases) and 44 months for patients with pAKT-positive expression (eight cases) (P=0.008). These results suggest that signalling from phosphatidylinositide 3-kinase/pAKT can lead to radiation resistance, and that evaluation of pAKT may be a prognostic marker for response to radiotherapy in LACC.
Keywords: cervical neoplasms; radiation resistance; pAKT; PI3K; immunohistochemistry
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
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