1. ¹Department of Clinical Epidemiology, Aarhus University Hospital, Ole Worms Allé 150, DK-8000, Aarhus C, Denmark
2. ²Department of Epidemiology, Institute of Public Health, Aarhus University, Vennelyst Boulevard 6, DK-8000, Aarhus C, Denmark
3. ³Department of Epidemiology, School of Public Health, Boston University, 715 Albany Street, TE3, Boston, MA 02118, USA

Correspondence: Dr V Langagergaard, E-mail: vl@dce.au.dk

Received 22 August 2005; Revised 3 October 2005; Accepted 26 October 2005; Published online 22 November 2005.

Abstract

We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8–17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0–2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3–6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients.