TABLE 2
FROM:
Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers
T C van Sprundel, M K Schmidt, M A Rookus, R Brohet, C J van Asperen, E J Th Rutgers, L J van't Veer and R A E M Tollenaar
BACK TO ARTICLETable 2. Characteristics of women who opted for CPM and women under surveillance
| Characteristic |
CPM group (N=79) |
Surveillance group (N=69) | P-value |
|---|---|---|---|
| Mutation status, N (%) | 0.693 | ||
| BRCA1 | 60 (75.9) | 55 (79.7) | |
| BRCA2 | 19 (24.1) | 14 (20.3) | |
| Age at mutation analysis (years) | |||
Mean s.e. | 41.50.9 | 46.71.1 | <0.001 |
| Range | 27–61 | 26–76 | |
| Age at CPM (years) | |||
| Means.e. | 41.90.9 | NA | |
| Range | 27–61 | NA | |
| Bilateral (salpingo-)oophorectomy, N (%) | 63 (79.7) | 46 (66.7) | 0.092 |
| Indication | |||
| Prophylactic | 61 (96.8) | 39 (84.8) | 0.009a |
| Ovarian carcinoma | 2 (3.2) | 4 (8.7) | |
| Metastasis breast cancer in ovary | — (0.0) | 1 (2.2) | |
| Adjuvant treatment first breast cancer | — (0.0) | 1 (2.2) | |
| Radiologic castration | — (0.0) | 1 (2.2) | |
| Age at bilateral prophylactic (salpingo-)oophorectomy (years) | |||
| Means.e. | 43.30.8 | 47.11.2 | 0.009 |
| Range | 30–60 | 35–64 | |
| Ipsilateral mastectomy (before or at the start of follow-up) | 79 (100) | 34 (49.3) | <0.001 |
CPM=contralateral prophylactic mastectomy; s.e.=standard error of the mean; NA=not applicable.
a Comparing prophylactic only.
