British Journal of Cancer - Table 4 for article: Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

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Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

D R Camidge, M N Pemberton, J W Growcott, D Johnstone, P J Laud, J R Foster, K J Randall and A M Hughes

Table 4. Immunohistochemistry marker quantification in healthy human buccal mucosa (Study A)

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Marker	Geometric mean^a	CV (%)^a	Minimum	Maximum
Phospho-HH3	2.14	76.87	0	7.94
p21	42.84	100.44	9.35	126.47
p53	6.74	167.9	0	32.88
Cyclin A	29.53	43.92	12.58	57.33
Cyclin E	55.18	41.93	28.14	86.88
Ki67	37.23	161.45	2.5	108.21
TUNEL	6.67	126.28	0.89	18.29

^a When calculating the geometric means and coefficients of variation (CVs) for phospho-HH3 and for p53, because the minimum values for both were zero, the limit of quantitation of the ULLI assay (1.0) was used as the minimum value.

TUNEL=terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling.

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TABLE 4

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Table 4. Immunohistochemistry marker quantification in healthy human buccal mucosa (Study A)