British Journal of Cancer

FIGURE 1

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Altered expression of topoisomerase IIalpha contributes to cross-resistant to etoposide K562/MX2 cell line by aberrant methylation

T Asano, K Nakamura, H Fujii, N Horichi, T Ohmori, K Hasegawa, T Isoe, M Adachi, N Otake and Y Fukunaga

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Figure 1.

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(A) Accumulation of MX2 in K562/P, K562/ADM and K562/MX cells. Intracellular accumulation of MX2 in K562/P, K562/ADM and K562/MX2 was measured according to Materials and Methods. Representative data from three independent experiments. Error bar showed s.d. (B) The efflux of MX2 in K562/P, K562/ADM and K562/MX2. The efflux of MX2 in K562/P, K562/ADM and K562/MX2 cells was measured according to Materials and Methods. Representative data from three independent experiments. Error bar showed s.d. (C) The accumulation of ADM in K562/P, K562/ADM and K562/MX cells. Intracellular accumulation of ADM in K562/P, K562/ADM and K562/MX2 was measured according to Materials and Methods. Representative data from three independent experiments. Error bar showed s.d. (D) The efflux of ADM in K562/P, K562/ADM and K562/MX2. The efflux of ADM in K562/P, K562/ADM and K562/MX2 cells was measured according to Materials and Methods. Representative data from three independent experiments. Error bar showed s.d.

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