TABLE 3
FROM:
Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy
A D Santin, F Zhan, S Cane', S Bellone, M Palmieri, M Thomas, A Burnett, J J Roman, M J Cannon, J Shaughnessy Jr and S Pecorelli
BACK TO ARTICLETable 3. Upregulated genes expressed at least 10-fold higher in NEC compared with USPC
| Probe set | Gene symbol | SAM | P of WRS | Ratio NEC/USPC | Title |
|---|---|---|---|---|---|
| 774_g_at | MYH11 | 17.611 | 0.0027 | 1014.968759 | 'Myosin, heavy polypeptide 11, smooth muscle' |
| 773_at | MYH11 | 14.265 | 0.0027 | 968.0223497 | 'Myosin, heavy polypeptide 11, smooth muscle' |
| 32582_at | MYH11 | 11.277 | 0.0027 | 212.2458648 | 'Myosin, heavy polypeptide 11, smooth muscle' |
| 36681_at | APOD | 11.714 | 0.0027 | 137.3140116 | Apolipoprotein D |
| 1501_at | IGF1 | 8.321 | 0.0027 | 128.0651104 | Insulin-like growth factor 1 (somatomedin C) |
| 39325_at | EBAF | 8.177 | 0.0027 | 123.064609 | 'Endometrial bleeding associated factor)' |
| 767_at | — | 12.707 | 0.0027 | 119.5409103 | — |
| 40398_s_at | MEOX2 | 10.182 | 0.0027 | 114.9489897 | Mesenchyme homeo box 2 |
| 40776_at | DES | 9.738 | 0.0027 | 109.416397 | Desmin |
| 1197_at | ACTG2 | 5.861 | 0.0027 | 96.65715109 | 'Actin, gamma 2, smooth muscle, enteric' |
| 36627_at | SPARCL1 | 7.724 | 0.0027 | 93.89302842 | 'SPARC-like 1 (mast9, hevin)' |
| 37407_s_at | MYH11 | 11.893 | 0.0027 | 88.70362054 | 'Myosin, heavy polypeptide 11, smooth muscle' |
| 39673_i_at | ECM2 | 8.459 | 0.0027 | 82.52353674 | 'Extracellular matrix protein 2, female organ and adipocyte specific' |
| 39701_at | PEG3 | 7.645 | 0.0027 | 73.87997223 | Paternally expressed gene 3 |
| 39066_at | MFAP4 | 9.383 | 0.0027 | 68.84723295 | Microfibrillar-associated protein 4 |
| 38737_at | IGF1 | 6.341 | 0.0027 | 65.13666715 | Insulin-like growth factor 1 (somatomedin C) |
| 35730_at | ADH1B | 9.759 | 0.0027 | 64.94146631 | 'Alcohol dehydrogenase IB (class I), beta polypeptide' |
| 41124_r_at | ENPP2 | 7.007 | 0.0027 | 53.43118221 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) |
| 36749_at | CPA3 | 9.096 | 0.0027 | 53.07347991 | Carboxypeptidase A3 (mast cell) |
| 39616_at | PTGER3 | 10.188 | 0.0027 | 52.65326101 | Prostaglandin E receptor 3 (subtype EP3) |
| 33440_at | TCF8 | 7.220 | 0.0027 | 49.54168001 | Transcription factor 8 |
| 32666_at | CXCL12 | 7.168 | 0.0027 | 49.2359637 | Chemokine (C–X–C motif) ligand 12 |
| 38734_at | PLN | 9.182 | 0.0027 | 47.86730799 | Phospholamban |
| 34203_at | CNN1 | 5.051 | 0.0027 | 47.0209722 | 'Calponin 1, basic, smooth muscle' |
| 37576_at | PCP4 | 12.468 | 0.0027 | 45.45542357 | Purkinje cell protein 4 |
| 36834_at | MOXD1 | 9.736 | 0.0027 | 44.20917891 | 'Monooxygenase, DBH-like 1' |
| 37247_at | TCF21 | 9.810 | 0.0027 | 42.40051895 | Transcription factor 21 |
| 37701_at | RGS2 | 7.408 | 0.0027 | 42.29038464 | 'Regulator of G-protein signalling 2, 24 kDa' |
| 779_at | COL4A6 | 5.840 | 0.0027 | 41.96325597 | 'Collagen, type IV, alpha 6' |
| 37394_at | C7 | 9.835 | 0.0027 | 40.72326307 | Complement component 7 |
| 36533_at | PTGIS | 6.097 | 0.0027 | 39.10052985 | Prostaglandin I2 (prostacyclin) synthase |
| 32689_s_at | — | 6.178 | 0.0027 | 36.96897988 | — |
| 32905_s_at | TPSB2 | 6.873 | 0.0027 | 36.85974711 | Tryptase beta 2 |
| 33240_at | SEMACAP3 | 4.814 | 0.0027 | 36.54583796 | Likely ortholog of mouse semaF cytoplasmic domain associated protein 3 |
| 1466_s_at | FGF7 | 8.628 | 0.0027 | 35.60413415 | Fibroblast growth factor 7 |
| 32686_at | PTGER3 | 7.397 | 0.0027 | 35.31357002 | Prostaglandin E receptor 3 (subtype EP3) |
| 39690_at | ALP | 6.951 | 0.0027 | 33.76045029 | Alpha-actinin-2-associated LIM protein |
| 38427_at | COL15A1 | 7.196 | 0.0027 | 32.85391153 | 'Collagen, type XV, alpha 1' |
| 39939_at | COL4A6 | 6.846 | 0.0027 | 32.53815505 | 'Collagen, type IV, alpha 6' |
| 37630_at | NRLN1 | 5.896 | 0.0027 | 31.03030255 | Neuralin 1 |
| 35717_at | ABCA8 | 7.587 | 0.0027 | 30.63819827 | 'ATP-binding cassette, subfamily A, member 8' |
| 1709_g_at | MAPK10 | 6.522 | 0.0027 | 30.54331363 | Mitogen-activated protein kinase 10 |
| 35679_s_at | DPP6 | 5.899 | 0.0027 | 30.33959319 | Dipeptidylpeptidase 6 |
| 35740_at | EMILIN1 | 7.445 | 0.0027 | 29.45261895 | Elastin microfibril interfacer 1 |
| 41123_s_at | ENPP2 | 6.597 | 0.0027 | 29.29614059 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) |
| 755_at | ITPR1 | 8.211 | 0.0027 | 29.02124207 | 'Inositol 1,4,5-triphosphate receptor, type 1' |
| 32847_at | MYLK | 5.388 | 0.0027 | 28.22518538 | 'Myosin, light polypeptide kinase' |
| 38001_at | CACNA1C | 5.740 | 0.0027 | 27.31347302 | 'Calcium channel, alpha 1C subunit' |
| 37279_at | GEM | 9.925 | 0.0027 | 26.56613192 | GTP-binding protein overexpressed in skeletal muscle |
| 36396_at | — | 5.901 | 0.0027 | 26.32457357 | Homo sapiens mRNA; cDNA DKFZp586N2020 (from clone DKFZp586N2020) |
| 41137_at | PPP1R12B | 12.043 | 0.0027 | 25.97089935 | 'Protein phosphatase 1, regulatory subunit 12B' |
| 41405_at | SFRP4 | 10.077 | 0.0027 | 23.90433923 | Secreted frizzled-related protein 4 |
| 40775_at | ITM2A | 6.152 | 0.0027 | 23.83083993 | Integral membrane protein 2A |
| 38059_g_at | DPT | 6.508 | 0.0027 | 23.76376781 | Dermatopontin |
| 41504_s_at | MAF | 5.331 | 0.0027 | 23.65323618 | v-maf |
| 1596_g_at | TEK | 4.542 | 0.0027 | 23.37422615 | 'TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)' |
| 914_g_at | ERG | 6.105 | 0.0027 | 22.63829292 | v-ets erythroblastosis virus E26 oncogene like |
| 34283_at | — | 5.390 | 0.0041 | 22.19917455 | 'Homo sapiens, clone IMAGE:4791553, mRNA' |
| 34388_at | COL14A1 | 9.452 | 0.0027 | 21.48165459 | 'Collagen, type XIV, alpha 1 (undulin)' |
| 38994_at | SOCS2 | 6.600 | 0.0027 | 21.47663968 | Suppressor of cytokine signaling 2 |
| 36065_at | LDB2 | 5.790 | 0.0027 | 21.19321308 | LIM domain binding 2 |
| 40230_at | FRZB | 5.962 | 0.0027 | 21.00467856 | Frizzled-related protein |
| 33790_at | CCL15 | 9.017 | 0.0027 | 20.5510028 | Chemokine (C–C motif) ligand 15 |
| 33890_at | RGS5 | 7.347 | 0.0027 | 20.2203337 | Regulator of G-protein signalling 5 |
| 36513_at | MAGP2 | 4.385 | 0.0041 | 20.10734871 | Microfibril-associated glycoprotein-2 |
| 32526_at | JAM3 | 6.129 | 0.0027 | 19.89641568 | Junctional adhesion molecule 3 |
| 32687_s_at | PTGER3 | 5.902 | 0.0027 | 19.7194642 | Prostaglandin E receptor 3 (subtype EP3) |
| 35638_at | CBFA2T1 | 10.470 | 0.0027 | 19.57233853 | 'Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related' |
| 34637_f_at | ADH1A | 6.291 | 0.0027 | 19.20847669 | 'Alcohol dehydrogenase 1A (class I)' |
| 34675_at | SBLF | 5.400 | 0.0027 | 19.04463285 | Stoned B-like factor |
| 38351_at | — | 5.899 | 0.0026 | 18.69131208 | Homo sapiens mRNA; cDNA DKFZp586L0120 (from clone DKFZp586L0120) |
| 1182_at | PLCL1 | 4.047 | 0.0027 | 18.50958764 | Phospholipase C-like 1 |
| 39681_at | ZNF145 | 6.266 | 0.0027 | 18.41823634 | 'Zinc-finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)' |
| 1708_at | MAPK10 | 6.336 | 0.0027 | 18.31250756 | Mitogen-activated protein kinase 10 |
| 37765_at | LMOD1 | 7.586 | 0.0027 | 18.11624265 | Leiomodin 1 (smooth muscle) |
| 1678_g_at | IGFBP5 | 4.237 | 0.0041 | 17.88349387 | Insulin-like growth factor binding protein 5 |
| 35358_at | TENC1 | 9.243 | 0.0027 | 17.68277053 | Tensin-like C1 domain-containing phosphatase |
| 33442_at | KIAA0367 | 6.830 | 0.0027 | 17.58195512 | KIAA0367 protein |
| 37249_at | PDE8B | 5.035 | 0.0027 | 17.25176904 | Phosphodiesterase 8B |
| 33834_at | CXCL12 | 7.736 | 0.0027 | 17.10893345 | Chemokine (C–X–C motif) ligand 12 (stromal cell-derived factor 1) |
| 35324_at | SLIT3 | 5.157 | 0.0027 | 17.08441711 | Slit homolog 3 (Drosophila) |
| 37015_at | ALDH1A1 | 4.941 | 0.0027 | 16.83181709 | 'Aldehyde dehydrogenase 1 family, member A1' |
| 39266_at | — | 6.237 | 0.0027 | 16.80733058 | Homo sapiens clone 24405 mRNA sequence |
| 33462_at | GPR105 | 4.907 | 0.0027 | 16.49634139 | G protein-coupled receptor 105 |
| 32488_at | COL3A1 | 3.928 | 0.0027 | 16.44993439 | 'Collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)' |
| 483_g_at | CDH13 | 3.755 | 0.0027 | 16.43857351 | 'Cadherin 13, H-cadherin (heart)' |
| 38026_at | FBLN1 | 5.350 | 0.0027 | 16.06497318 | Fibulin 1 |
| 1909_at | BCL2 | 7.356 | 0.0027 | 16.01160367 | B-cell CLL/lymphoma 2 |
| 36245_at | HTR2B | 4.698 | 0.0027 | 15.77119379 | 5-Hydroxytryptamine (serotonin) receptor 2B |
| 32057_at | LRRC17 | 5.470 | 0.0027 | 15.6891271 | Leucine-rich repeat containing 17 |
| 39544_at | DMN | 5.361 | 0.0027 | 15.66465434 | Desmuslin |
| 37112_at | C6orf32 | 4.720 | 0.0027 | 15.65975413 | Chromosome 6 open reading frame 32 |
| 36733_at | FLJ32389 | 4.442 | 0.0027 | 15.64273348 | Hypothetical protein FLJ32389 |
| 1319_at | DDR2 | 5.400 | 0.0027 | 15.5817123 | 'Discoidin domain receptor family, member 2' |
| 38057_at | DPT | 8.479 | 0.0027 | 15.51358362 | Dermatopontin |
| 40358_at | GLI3 | 6.650 | 0.0027 | 15.11249492 | GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) |
| 38627_at | HLF | 4.947 | 0.0027 | 14.89249894 | Hepatic leukemia factor |
| 1731_at | PDGFRA | 7.050 | 0.0027 | 14.84422948 | 'Platelet-derived growth factor receptor, alpha polypeptide' |
| 31897_at | DOC1 | 4.664 | 0.0027 | 14.80084961 | Downregulated in ovarian cancer 1 |
| 2073_s_at | CDH13 | 5.076 | 0.0027 | 14.79118507 | 'Cadherin 13, H-cadherin (heart)' |
| 38577_at | — | 7.283 | 0.0027 | 14.78670234 | 'Clone DT1P1B6 mRNA, CAG repeat region' |
| 38004_at | CSPG4 | 6.072 | 0.0027 | 14.40637488 | Chondroitin sulphate proteoglycan 4 |
| 32109_at | FXYD1 | 7.333 | 0.0027 | 14.33463902 | Phospholemman |
| 34853_at | FLRT2 | 9.834 | 0.0027 | 14.33080432 | Fibronectin leucine-rich transmembrane protein 2 |
| 38298_at | KCNMB1 | 7.046 | 0.0027 | 14.25816751 | 'Potassium large-conductance calcium-activated channel, subfamily M, beta member 1' |
| 41245_at | GDF10 | 6.643 | 0.0027 | 14.21467179 | Growth differentiation factor 10 |
| 38322_at | GAGEC1 | 6.215 | 0.0027 | 14.10508119 | 'G antigen, family C, 1' |
| 1198_at | EDNRB | 4.899 | 0.0027 | 14.08196951 | Endothelin receptor type B |
| 41505_r_at | MAF | 4.528 | 0.0027 | 14.0059518 | v-maf |
| 36976_at | CDH11 | 3.692 | 0.0027 | 14.00329993 | 'Cadherin 11, type 2, OB-cadherin (osteoblast)' |
| 32688_at | PTGER3 | 4.998 | 0.0027 | 13.68791213 | Prostaglandin E receptor 3 (subtype EP3) |
| 1575_at | ABCB1 | 6.210 | 0.0027 | 13.64196645 | 'ATP-binding cassette, subfamily B' |
| 32778_at | ITPR1 | 4.914 | 0.0027 | 13.60359986 | 'Inositol 1,4,5-triphosphate receptor, type 1' |
| 40737_at | KCNMA1 | 5.642 | 0.0027 | 13.60011778 | 'potassium large-conductance calcium-activated channel, subfamily M, alpha member 1' |
| 36569_at | TNA | 11.512 | 0.0027 | 13.14186685 | Tetranectin (plasminogen-binding protein) |
| 1897_at | TGFBR3 | 4.922 | 0.0041 | 12.99722509 | 'Transforming growth factor, beta receptor III (betaglycan, 300 kDa)' |
| 2087_s_at | CDH11 | 4.345 | 0.0027 | 12.96131894 | 'Cadherin 11, type 2, OB-cadherin (osteoblast)' |
| 34820_at | PTN | 4.413 | 0.0041 | 12.94626537 | 'Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)' |
| 743_at | NAP1L3 | 7.859 | 0.0027 | 12.91061134 | Nucleosome assembly protein 1-like 3 |
| 1507_s_at | EDNRA | 4.319 | 0.0041 | 12.88466839 | Endothelin receptor type A |
| 38995_at | CLDN5 | 12.156 | 0.0027 | 12.86636376 | Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) |
| 1147_at | — | 7.084 | 0.0027 | 12.69931721 | — |
| 1954_at | KDR | 6.077 | 0.0027 | 12.6174344 | Kinase insert domain receptor (a type III receptor tyrosine kinase) |
| 38786_at | — | 5.676 | 0.0027 | 12.61170471 | Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 248114 |
| 40757_at | GZMA | 4.575 | 0.0041 | 12.56281091 | 'Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)' |
| 36695_at | na | 5.776 | 0.0027 | 12.53905775 | Similar to hypothetical protein 6720478C22 |
| 32052_at | HBB | 5.107 | 0.0063 | 12.52262761 | 'Haemoglobin, beta' |
| 37446_at | GASP | 8.227 | 0.0027 | 12.39360585 | G protein-coupled receptor-associated protein |
| 38038_at | LUM | 4.462 | 0.0027 | 12.34757673 | Lumican |
| 32889_at | RPIB9 | 6.337 | 0.0027 | 12.34540513 | Rap2-binding protein 9 |
| 35234_at | RECK | 4.476 | 0.0027 | 12.33793353 | Reversion-inducing-cysteine-rich protein |
| 661_at | GAS1 | 4.648 | 0.0027 | 12.32556384 | Growth arrest-specific 1 |
| 41195_at | LPP | 6.292 | 0.0027 | 12.26636801 | LIM domain containing preferred translocation partner in lipoma |
| 32664_at | RNASE4 | 6.395 | 0.0027 | 11.89680804 | 'Ribonuclease, RNase A family, 4' |
| 39038_at | FBLN5 | 4.325 | 0.0027 | 11.89440528 | Fibulin 5 |
| 40693_at | KCNB1 | 4.952 | 0.0041 | 11.84773944 | 'Potassium voltage-gated channel, Shab-related subfamily, member 1' |
| 38052_at | F13A1 | 5.346 | 0.0027 | 11.69181717 | 'Coagulation factor XIII, A1 polypeptide' |
| 35220_at | ENPEP | 4.200 | 0.0027 | 11.66308093 | Glutamyl aminopeptidase (aminopeptidase A) |
| 37512_at | RODH | 5.112 | 0.0027 | 11.65031202 | 3-Hydroxysteroid epimerase |
| 103_at | THBS4 | 5.114 | 0.0027 | 11.6063075 | Thrombospondin 4 |
| 36156_at | AQP1 | 6.927 | 0.0027 | 11.6016663 | 'Aquaporin 1' |
| 39593_at | FGL2 | 5.176 | 0.0027 | 11.38223584 | Fibrinogen-like 2 |
| 33248_at | HOXA11 | 6.555 | 0.0027 | 11.34828098 | Homeo box A11 |
| 41420_at | IGFBP5 | 4.166 | 0.0041 | 11.32365037 | Insulin-like growth factor binding protein 5 |
| 35644_at | HEPH | 6.666 | 0.0027 | 11.26324425 | Hephaestin |
| 39646_at | CACNB2 | 4.719 | 0.0027 | 11.25017414 | 'Calcium channel, voltage-dependent, beta 2 subunit' |
| 35333_r_at | DVS27 | 4.403 | 0.0027 | 11.23759398 | DVS27-related protein |
| 33182_at | — | 4.990 | 0.0027 | 11.20258783 | Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 1630957 |
| 34303_at | FLJ90798 | 4.909 | 0.0027 | 11.10458088 | Hypothetical protein FLJ90798 |
| 33756_at | AOC3 | 5.186 | 0.0027 | 11.09776026 | 'Amine oxidase, copper containing 3 (vascular adhesion protein 1)' |
| 37710_at | MEF2C | 7.485 | 0.0027 | 11.03832245 | 'MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)' |
| 35680_r_at | DPP6 | 3.783 | 0.0027 | 10.88151987 | Dipeptidylpeptidase 6 |
| 40126_at | — | 4.620 | 0.0027 | 10.87424764 | — |
| 31831_at | SMTN | 5.712 | 0.0027 | 10.84917408 | Smoothelin |
| 234_s_at | PTN | 5.660 | 0.0041 | 10.803161 | 'Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)' |
| 36939_at | GPM6A | 4.981 | 0.0027 | 10.76644676 | Glycoprotein M6A |
| 41158_at | PLP1 | 4.879 | 0.0027 | 10.76462278 | 'Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)' |
| 41839_at | GAS1 | 4.401 | 0.0027 | 10.75375673 | Growth arrest-specific 1 |
| 1186_at | GDF10 | 4.165 | 0.0063 | 10.74677086 | Growth differentiation factor 10 |
| 35404_at | TACR2 | 4.416 | 0.0063 | 10.67366905 | Tachykinin receptor 2 |
| 160023_at | WNT2 | 5.424 | 0.0027 | 10.67077677 | Wingless-type MMTV integration site family member 2 |
| 34561_at | MS4A2 | 6.380 | 0.0027 | 10.6336763 | 'Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)' |
| 36280_at | GZMK | 4.739 | 0.0027 | 10.5607572 | 'Granzyme K' |
| 35668_at | RAMP1 | 3.430 | 0.0027 | 10.4886967 | Receptor (calcitonin) activity modifying protein 1 |
| 32521_at | SFRP1 | 4.488 | 0.0027 | 10.43051698 | Secreted frizzled-related protein 1 |
| 1975_s_at | IGF1 | 7.381 | 0.0027 | 10.34307322 | Insulin-like growth factor 1 (somatomedin C) |
| 37671_at | LAMA4 | 5.094 | 0.0027 | 10.34084543 | 'Laminin, alpha 4' |
| 40013_at | CLIC2 | 5.388 | 0.0027 | 10.2736905 | Chloride intracellular channel 2 |
| 32782_r_at | BPAG1 | 4.597 | 0.0027 | 10.2197061 | 'Bullous pemphigoid antigen 1, 230/240 kDa' |
| 36918_at | GUCY1A3 | 4.344 | 0.0027 | 10.18606373 | 'Guanylate cyclase 1, soluble, alpha 3' |
| 32239_at | MATN2 | 6.197 | 0.0027 | 10.14895891 | Matrilin 2 |
| 36503_at | CCL21 | 6.812 | 0.0027 | 10.09354903 | Chemokine (C–C motif) ligand 21 |
| 38508_s_at | TNXB | 8.826 | 0.0027 | 10.0794719 | Tenascin XB |
| 35146_at | TGFB1I1 | 5.562 | 0.0027 | 10.0680837 | Transforming growth factor beta 1 |
| 38653_at | PMP22 | 6.085 | 0.0027 | 10.04665889 | Peripheral myelin protein 22 |
| 342_at | ENPP1 | 5.008 | 0.0041 | 10.0434301 | Ectonucleotide pyrophosphatase/phosphodiesterase |
| 32826_at | ENTPD1 | 6.423 | 0.0027 | 10.01186286 | Ectonucleoside triphosphate diphosphohydrolase 1 |
| 40318_at | DNCI1 | 3.348 | 0.0063 | 10.00454416 | 'Dynein, cytoplasmic, intermediate polypeptide 1' |
