TABLE 2
FROM:
Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy
A D Santin, F Zhan, S Cane', S Bellone, M Palmieri, M Thomas, A Burnett, J J Roman, M J Cannon, J Shaughnessy Jr and S Pecorelli
BACK TO ARTICLETable 2. Upregulated genes expressed at least five-fold higher in USPC compared with NEC
| Probe set | Gene symbol | SAM | P of WRS | Ratio USPC/NEC | Title |
|---|---|---|---|---|---|
| 1713_s_at | CDKN2A a | 10.592 | 0.0027 | 101.9077377 | 'Cyclin-dependent kinase inhibitor 2A (melanoma, p16)' |
| 36288_at | KRTHB1 | 4.573 | 0.0027 | 77.3983986 | 'Keratin, hair, basic, 1' |
| 33272_at | SAA1 | 3.778 | 0.0063 | 45.74937337 | Serum amyloid A1 |
| 41294_at | KRT7 | 7.173 | 0.0027 | 41.46788873 | Keratin 7 |
| 32154_at | TFAP2A | 7.637 | 0.0027 | 32.47929396 | Transcription factor AP-2 alpha |
| 31610_at | MAP17 | 3.621 | 0.0093 | 30.28302802 | Membrane-associated protein 17 |
| 408_at | — | 4.070 | 0.0063 | 30.14111158 | — |
| 32821_at | LCN2 | 5.126 | 0.0027 | 27.69975608 | Lipocalin 2 (oncogene 24p3) |
| 35174_i_at | EEF1A2 | 2.840 | 0.0278 | 26.80482891 | Elongation factor 1 alpha 2 |
| 38551_at | L1CAM | 3.115 | 0.0196 | 25.60938089 | 'L1 cell adhesion molecule |
| 38249_at | VGLL1 | 5.274 | 0.0027 | 24.69495091 | Vestigial like 1 (Drosophila) |
| 35879_at | GAL | 5.594 | 0.0027 | 23.48953559 | Galanin |
| 36838_at | KLK10 | 3.455 | 0.0136 | 23.17518549 | Kallikrein 10 |
| 38299_at | IL6 | 3.630 | 0.0041 | 19.05873079 | 'Interleukin 6 (interferon, beta 2)' |
| 38051_at | MAL | 4.878 | 0.0041 | 17.51555106 | 'mal, T-cell differentiation protein' |
| 41469_at | PI3 | 2.854 | 0.0063 | 16.90464558 | 'Protease inhibitor 3, skin-derived (SKALP)' |
| 40412_at | PTTG1 | 5.218 | 0.0027 | 16.61222352 | Pituitary tumour-transforming 1 |
| 1886_at | WNT7A | 3.544 | 0.0196 | 16.11519778 | 'Wingless-type MMTV integration site family, member 7A' |
| 33128_s_at | CST6 | 4.222 | 0.0136 | 15.97856318 | Cystatin E/M |
| 38414_at | CDC20 | 7.317 | 0.0027 | 15.64601435 | CDC20 cell division cycle 20 homolog (S. cerevisiae) |
| 34012_at | KRTHA4 | 2.411 | 0.0278 | 15.37247475 | 'Keratin, hair, acidic, 4' |
| 37554_at | KLK6 | 3.785 | 0.0093 | 15.23781352 | 'Kallikrein 6 (neurosin, zyme)' |
| 1802_s_at | ERBB2 | 2.566 | 0.0136 | 14.52012028 | 'v-erb-b2' |
| 41060_at | CCNE1 | 6.092 | 0.0027 | 14.16647068 | Cyclin E1 |
| 36837_at | KIF2C | 6.130 | 0.0027 | 14.1328483 | Kinesin family member 2C |
| 34213_at | KIBRA | 5.301 | 0.0027 | 13.27228177 | KIBRA protein |
| 1651_at | UBE2C | 5.554 | 0.0027 | 12.87617243 | Ubiquitin-conjugating enzyme E2C |
| 35276_at | CLDN4 | 6.381 | 0.0027 | 12.74825421 | Claudin 4 |
| 36990_at | UCHL1 | 4.623 | 0.0027 | 12.30505908 | Ubiquitin carboxyl-terminal esterase L1 |
| 35977_at | DKK1 | 4.495 | 0.0041 | 12.25382636 | Dickkopf homolog 1 (Xenopus laevis) |
| 36113_s_at | TNNT1 | 4.072 | 0.0027 | 11.93824813 | 'Troponin T1, skeletal, slow' |
| 2011_s_at | BIK | 3.451 | 0.0063 | 11.66959681 | BCL2-interacting killer (apoptosis-inducing) |
| 543_g_at | CRABP1 | 3.193 | 0.0093 | 11.55494382 | Cellular retinoic acid binding protein 1 |
| 34852_g_at | STK6 | 6.225 | 0.0027 | 11.51812047 | Serine/threonine kinase 6 |
| 33483_at | NMU | 4.094 | 0.0027 | 11.42057993 | Neuromedin U |
| 39109_at | TPX2 | 6.162 | 0.0027 | 11.29208457 | 'TPX2, microtubule-associated protein homologue' |
| 37018_at | HIST1H1C | 2.270 | 0.0278 | 10.74270622 | 'Histone 1, H1c' |
| 1165_at | IL18 | 3.221 | 0.0041 | 10.65596528 | Interleukin 18 (interferon-gamma-inducing factor) |
| 36477_at | TNNI3 | 2.867 | 0.0136 | 10.61101382 | 'Troponin I, cardiac' |
| 572_at | TTK | 3.720 | 0.0093 | 9.723902052 | TTK protein kinase |
| 31542_at | FLG | 2.622 | 0.0196 | 9.600831601 | Filaggrin |
| 35937_at | MICB | 4.238 | 0.0093 | 9.460109582 | MHC class I polypeptide-related sequence B |
| 36155_at | SPOCK2 | 2.278 | 0.0278 | 9.216570003 | 'Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2' |
| 32186_at | SLC7A5 | 4.149 | 0.0063 | 9.121679665 | 'Solute carrier family 7 (cationic amino-acid transporter, y+ system), member 5' |
| 35766_at | KRT18 | 5.933 | 0.0027 | 9.01220054 | Keratin 18 |
| 35822_at | BF | 3.267 | 0.0063 | 8.952514469 | 'B-factor, properdin' |
| 35714_at | PDXK | 6.550 | 0.0027 | 8.898191704 | 'Pyridoxal (pyridoxine, vitamin B6) kinase' |
| 1369_s_at | — | 2.679 | 0.0196 | 8.773380878 | — |
| 40079_at | RAI3 | 4.516 | 0.0063 | 8.626843209 | Retinoic acid induced 3 |
| 37168_at | LAMP3 | 2.838 | 0.0136 | 8.616807346 | Lysosomal-associated membrane protein 3 |
| 39704_s_at | HMGA1 | 5.322 | 0.0027 | 8.597894471 | High-mobility group AT-hook 1 |
| 1887_g_at | WNT7A | 3.003 | 0.0196 | 8.491813649 | 'Wingless-type MMTV integration site family, member 7A' |
| 36929_at | LAMB3 | 5.770 | 0.0027 | 8.354149098 | 'Laminin, beta 3' |
| 527_at | CENPA | 6.126 | 0.0027 | 8.32992789 | 'Centromere protein A, 17 kDa' |
| 41081_at | BUB1 | 4.883 | 0.0027 | 8.213759056 | BUB1 budding uninhibited by benzimidazoles 1 homologue |
| 885_g_at | ITGA3 | 4.447 | 0.0027 | 8.20660555 | 'Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)' |
| 2021_s_at | CCNE1 | 4.399 | 0.0041 | 8.199388463 | Cyclin E1 |
| 33904_at | CLDN3 | 3.296 | 0.0136 | 8.020010794 | Claudin 3 |
| 33730_at | RAI3 | 4.648 | 0.0041 | 7.923899439 | Retinoic acid induced 3 |
| 34736_at | CCNB1 | 5.078 | 0.0063 | 7.896644626 | Cyclin B1 |
| 757_at | ANXA2 | 3.514 | 0.0063 | 7.870466864 | Annexin A2 |
| 910_at | TK1 | 3.934 | 0.0093 | 7.869091533 | 'Thymidine kinase 1, soluble' |
| 34851_at | STK6 | 4.491 | 0.0041 | 7.764803777 | Serine/threonine kinase 6 |
| 34703_f_at | — | 2.275 | 0.0278 | 7.710260816 | — |
| 34715_at | FOXM1 | 5.318 | 0.0027 | 7.659023602 | Forkhead box M1 |
| 38971_r_at | TNIP1 | 6.800 | 0.0027 | 7.595036872 | TNFAIP3 interacting protein 1 |
| 32263_at | CCNB2 | 4.246 | 0.0063 | 7.578513543 | Cyclin B2 |
| 1680_at | GRB7 | 4.013 | 0.0027 | 7.471384928 | Growth factor receptor-bound protein 7 |
| 38247_at | F2RL1 | 3.185 | 0.0093 | 7.432476326 | Coagulation factor II (thrombin) receptor-like 1 |
| 160025_at | TGFA | 6.088 | 0.0027 | 7.355344272 | 'Transforming growth factor, alpha' |
| 1945_at | CCNB1 | 5.298 | 0.0041 | 7.291039832 | Cyclin B1 |
| 31792_at | ANXA3 | 4.873 | 0.0041 | 7.266892828 | Annexin A3 |
| 182_at | ITPR3 | 5.432 | 0.0027 | 7.172450367 | 'Inositol 1,4,5-triphosphate receptor, type 3' |
| 1117_at | CDA | 2.937 | 0.0093 | 7.114518646 | Cytidine deaminase |
| 902_at | EPHB2 | 5.186 | 0.0027 | 7.065363569 | EphB2 |
| 634_at | PRSS8 | 5.216 | 0.0041 | 7.001894703 | 'Protease, serine, 8 (prostasin)' |
| 41169_at | PLAUR | 3.982 | 0.0063 | 7.00139089 | 'Plasminogen activator, urokinase receptor' |
| 33203_s_at | FOXD1 | 3.464 | 0.0093 | 6.989749222 | Forkhead box D1 |
| 40095_at | CA2 | 4.285 | 0.0027 | 6.946396937 | Carbonic anhydrase II |
| 38940_at | AD024 | 5.065 | 0.0041 | 6.928406028 | AD024 protein |
| 34348_at | SPINT2 | 6.263 | 0.0027 | 6.877224695 | 'Serine protease inhibitor, Kunitz type, 2' |
| 33933_at | WFDC2 | 3.344 | 0.0136 | 6.820073691 | WAP four-disulphide core domain 2 |
| 35281_at | LAMC2 | 3.347 | 0.0093 | 6.7580474 | 'Laminin, gamma 2' |
| 349_g_at | KIFC1 | 5.275 | 0.0041 | 6.700913018 | Kinesin family member C1 |
| 33218_at | ERBB2 | 2.710 | 0.0027 | 6.615105998 | 'v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)' |
| 38881_i_at | TRIM16 | 3.001 | 0.0196 | 6.506893575 | Tripartite motif-containing 16 |
| 1536_at | CDC6 | 4.666 | 0.0041 | 6.463305623 | CDC6 cell division cycle 6 homolog (S. cerevisiae) |
| 38482_at | CLDN7 | 4.931 | 0.0041 | 6.409117877 | Claudin 7 |
| 40697_at | CCNA2 | 3.396 | 0.0093 | 6.40768505 | Cyclin A2 |
| 41688_at | TM4SF11 | 4.390 | 0.0027 | 6.366861533 | Transmembrane 4 superfamily member 11 (plasmolipin) |
| 38158_at | ESPL1 | 6.007 | 0.0027 | 6.225688779 | Extra spindle poles like 1 (S. cerevisiae) |
| 38474_at | CBS | 3.380 | 0.0093 | 6.212078913 | Cystathionine-beta-synthase |
| 36483_at | GALNT3 | 3.890 | 0.0041 | 6.181109111 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) |
| 35372_r_at | IL8 | 2.360 | 0.0278 | 6.133149591 | Interleukin 8 |
| 41585_at | KIAA0746 | 4.436 | 0.0027 | 6.092207586 | KIAA0746 protein |
| 36832_at | B3GNT3 | 5.457 | 0.0027 | 5.941291793 | 'UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3' |
| 1107_s_at | G1P2 | 3.938 | 0.0063 | 5.923287019 | 'Interferon, alpha-inducible protein (clone IFI-15K)' |
| 35207_at | SCNN1A | 3.076 | 0.0136 | 5.920739634 | 'Sodium channel, nonvoltage-gated 1 alpha' |
| 36863_at | HMMR | 2.830 | 0.0196 | 5.905038013 | Hyaluronan-mediated motility receptor (RHAMM) |
| 38631_at | TNFAIP2 | 4.924 | 0.0027 | 5.897745642 | 'Tumour necrosis factor, alpha-induced protein 2' |
| 36813_at | TRIP13 | 5.666 | 0.0027 | 5.870351247 | Thyroid hormone receptor interactor 13 |
| 41048_at | PMAIP1 | 3.490 | 0.0062 | 5.853172336 | Phorbol-12-myristate-13-acetate-induced protein 1 |
| 2084_s_at | ETV4 | 3.743 | 0.0093 | 5.798002338 | 'ets variant gene 4 (E1A enhancer binding protein, E1AF)' |
| 33245_at | MAPK13 | 3.775 | 0.0136 | 5.766618762 | Mitogen-activated protein kinase 13 |
| 37347_at | CKS1B | 5.543 | 0.0027 | 5.762817533 | CDC28 protein kinase regulatory subunit 1B |
| 34282_at | NFE2L3 | 2.668 | 0.0136 | 5.734907375 | Nuclear factor (erythroid-derived 2)-like 3 |
| 330_s_at | — | 4.026 | 0.0041 | 5.726752495 | — |
| 41732_at | na | 6.920 | 0.0027 | 5.706487141 | Similar to My016 protein |
| 1516_g_at | — | 6.726 | 0.0027 | 5.63870137 | — |
| 904_s_at | TOP2A | 3.419 | 0.0063 | 5.634251452 | Topoisomerase (DNA) II alpha 170 kDa |
| 36041_at | EXO1 | 4.971 | 0.0027 | 5.59235892 | Exonuclease 1 |
| 33143_s_at | SLC16A3 | 4.007 | 0.0063 | 5.56591457 | 'Solute carrier family 16 (monocarboxylic acid transporters), member 3' |
| 37228_at | PLK | 4.501 | 0.0041 | 5.564532365 | Polo-like kinase (Drosophila) |
| 1854_at | MYBL2 | 4.117 | 0.0063 | 5.54317592 | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 |
| 40407_at | KPNA2 | 4.189 | 0.0041 | 5.51635645 | 'Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)' |
| 33282_at | LAD1 | 3.904 | 0.0063 | 5.509367036 | Ladinin 1 |
| 40145_at | TOP2A | 3.307 | 0.0093 | 5.48127065 | Topoisomerase (DNA) II alpha 170 kDa |
| 1100_at | IRAK1 | 5.530 | 0.0027 | 5.470162749 | Interleukin-1 receptor-associated kinase 1 |
| 37883_i_at | AF038169 | 3.160 | 0.0027 | 5.460495655 | Hypothetical protein AF038169 |
| 37343_at | ITPR3 | 5.258 | 0.0027 | 5.449013729 | 'Inositol 1,4,5-triphosphate receptor, type 3' |
| 31598_s_at | GALE | 4.647 | 0.0027 | 5.442955253 | 'Galactose-4-epimerase, UDP-' |
| 889_at | ITGB8 | 2.744 | 0.0093 | 5.370592815 | 'Integrin, beta 8' |
| 37558_at | IMP-3 | 3.123 | 0.0093 | 5.364127468 | IGF-II mRNA-binding protein 3 |
| 32715_at | VAMP8 | 5.686 | 0.0027 | 5.352873419 | Vesicle-associated membrane protein 8 (endobrevin) |
| 36312_at | SERPINB8 | 3.611 | 0.0027 | 5.327343554 | 'Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8' |
| 37210_at | INA | 3.551 | 0.0063 | 5.307526088 | 'Internexin neuronal intermediate filament protein, alpha' |
| 35699_at | BUB1B | 3.665 | 0.0196 | 5.279075308 | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) |
| 32787_at | ERBB3 | 2.658 | 0.0041 | 5.247404657 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
| 32275_at | SLPI | 3.726 | 0.0041 | 5.221163981 | Secretory leukocyte protease inhibitor (antileukoproteinase) |
| 893_at | E2-EPF | 3.775 | 0.0063 | 5.196412396 | Ubiquitin carrier protein |
| 41583_at | FEN1 | 5.481 | 0.0027 | 5.196005796 | Flap structure-specific endonuclease 1 |
| 41781_at | PPFIA1 | 4.113 | 0.0027 | 5.194931774 | 'Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1' |
| 40726_at | KIF11 | 2.941 | 0.0093 | 5.1806793 | Kinesin family member 11 |
| 41400_at | TK1 | 4.246 | 0.0093 | 5.167172588 | 'Thymidine kinase 1, soluble' |
| 41409_at | C1orf38 | 3.109 | 0.0063 | 5.100239097 | Chromosome 1 open reading frame 38 |
| 40425_at | EFNA1 | 2.738 | 0.0196 | 5.067718102 | Ephrin-A1 |
| 32081_at | CIT | 6.162 | 0.0027 | 5.043567722 | 'Citron (rho-interacting, serine/threonine kinase 21)' |
| 1108_s_at | EPHA1 | 4.864 | 0.0027 | 5.040980858 | EphA1 |
| 33338_at | STAT1 | 3.275 | 0.0063 | 5.029498048 | 'Signal transducer and activator of transcription 1, 91 kDa' |
a Genes selected for further analysis are identified with bold letters.
