1. ¹Department of Medical Genetics, Biomedicum Helsinki (Haartmaninkatu 8), University of Helsinki, Helsinki FIN-00014, Finland
2. ²Molecular Cancer Biology Program, Institute of Biomedicine and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland
3. ³Laboratory of Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
4. ⁴Unfallchirurgie, Universitätsklinikum, Heinrich Heine Universität, Düsseldorf, Germany
5. ⁵Allgemein- und Viszeralchirurgie, Universitätsklinikum, Heinrich Heine Universität, Düsseldorf, Germany
6. ⁶Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44, Lincoln's Inn Fields, London WC2A 3PX, UK

Correspondence: Dr V Launonen, E-mail: virpi.launonen@helsinki.fi

Received 19 May 2004; Revised 1 January 2005; Accepted 11 January 2004; Published online 8 March 2005.

Abstract

Mutations in LKB1 lead to Peutz–Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD, and MO25, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.