Molecular Diagnostics

British Journal of Cancer (2005) 92, 891–894. doi:10.1038/sj.bjc.6602436 www.bjcancer.com
Published online 1 March 2005

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

M Moberg1, I Gustavsson1, E Wilander1 and U Gyllensten1

1Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 751 85, Sweden

Correspondence: Dr U Gyllensten, E-mail: ulf.gyllensten@genpat.uu.se

Received 28 July 2004; Revised 13 December 2004; Accepted 4 January 2005; Published online 1 March 2005.

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Abstract

High loads of human papillomavirus (HPV) 16 and HPV 18/45 increase the risk of developing invasive cervical carcinoma, revealing higher risk in percentiles of highest viral loads for HPV 16 (odds ratio (OR) 58.7, 95% confidence interval (CI) 21.9–151.4) compared to HPV 18/45 (OR 3.3, 95% CI 1.5–7.2). Thus, HPV load is a type-dependent risk marker for invasive carcinoma.

Keywords:

human papillomavirus, invasive cervical cancer, viral load

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