1. ¹Department of Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan
2. ²CREST Research Project, Japan Science and Technology Corporation, Kawaguchi-shi, Saitama 332-0012, Japan
3. ³Shinanomachi Research Park, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan
4. ⁴Division of Virology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan

Correspondence: Dr M Kuroda, Department of Pathology, Tokyo Medical University, 6-1-1, Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan. E-mail: kuroda@tokyo-med.ac.jp

⁵These authors contributed equally

Received 31 August 2004; Revised 12 October 2004; Accepted 15 October 2004; Published online 11 January 2005.

Abstract

Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.