Translational Therapeutics
British Journal of Cancer (2005) 92, 294–297. doi:10.1038/sj.bjc.6602324 www.bjcancer.com
Published online 18 January 2005
Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
Y Zlotnik1, M Patya1, A Vanichkin1 and A Novogrodsky1
1Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah-Tikva 49100, Israel
Correspondence: Dr A Novogrodsky, E-mail: novog@post.tau.ac.il
Received 23 September 2004; Accepted 3 October 2004; Published online 18 January 2005.
Abstract
Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.
Keywords:
tyrphostins, chemotherapy, chemoprotection, intestinal injury, gamma-glutamyl transpeptidase
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