TABLE 1
FROM:
Role of novel targeted therapies in the clinic
R S Herbst
BACK TO ARTICLETable 1. Activity profile of molecular-targeted agents
| Single target | Multiple target |
|---|---|
| Bevacizumab (anti-VEGF MAb) | BAY 43-9006 (Raf-1, VEGFR-2 and -3, and PDGFR- ) |
| Cetuximab (EGFR MAb) | PTK787 (VEGFR-1, -2 and -3, PDGFR- and c-Kit) |
| IMC-1121b (VEGFR-2 MAb) | SU11248 (VEGFR-1, -2 and -3, Flt-3, PDGFR, c-Kit and CSF-1) |
| ZD6474 (VEGFR and EGFR) | |
| AEE-788 (VEGFR, EGFR, erb) | |
| AMG 706 (VEGFR, PDGFR, c-Kit and Ret) | |
