Epidemiology
British Journal of Cancer (2005) 92, 2039–2041. doi:10.1038/sj.bjc.6602608 www.bjcancer.com
Published online 10 May 2005
Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case–control study
C Lilla1, T Koehler2, S Kropp1, S Wang-Gohrke2 and J Chang-Claude1
- 1Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
- 2Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Frauensteige 14, Ulm 89075, Germany
Correspondence: Dr S Wang-Gohrke or Professor J Chang-Claude, E-mails: shan.wang@medizin.uni-ulm.de or j.chang-claude@dkfz-heidelberg.de
Received 10 January 2005; Revised 30 March 2005; Accepted 1 April 2005; Published online 10 May 2005.
Abstract
In a population-based study of 613 cases and 1082 controls, alcohol dehydrogenase 1B (ADH1B) genotype was not an independent risk factor for breast cancer, athough the possibility was raised that it modifies risk associated with high levels of alcohol consumption (OR 1.1, 95% confidence interval (CI) 0.8–1.6 for ADH1B*1/*1 genotype vs 0.2, 95% CI 0.1–1.0 for ADH1B*2 carriers).
Keywords:
alcohol dehydrogenase, polymorphism, gene–environment interaction, breast cancer
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
RESEARCH
A common coding variant in CASP8 is associated with breast cancer risk
Nature Genetics Letter (01 Mar 2007)
British Journal of Cancer Original Article
British Journal of Cancer Scientific Correspondence
