Table of contents

Volume 90, Issue 8
Published online 13 April 2004 (1469-1689)

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Minireview

Targeted radiotherapy of brain tumours FREE

M R Zalutsky

Br J Cancer 90: 1469-1473; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601771

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Clinical

Information needs of Asian and White British cancer patients and their families in Leicestershire: a cross-sectional survey FREE

D Muthu Kumar, R P Symonds, S Sundar, K Ibrahim, B S P Savelyich and E Miller

Br J Cancer 90: 1474-1478; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601774

Factors influencing time from presentation to treatment of colorectal and breast cancer in urban and rural areas FREE

R Robertson, N C Campbell, S Smith, P T Donnan, F Sullivan, R Duffy, L D Ritchie, D Millar, J Cassidy and A Munro

Br J Cancer 90: 1479-1485; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601753

Stage and treatment variation with age in postmenopausal women with breast cancer: compliance with guidelines FREE

L Wyld, D K Garg, I D Kumar, H Brown and M W R Reed

Br J Cancer 90: 1486-1491; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601742

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up FREE

R I Olivier, M van Beurden, M A C Lubsen, M A Rookus, T M Mooij, M J van de Vijver and L J van't Veer

Br J Cancer 90: 1492-1497; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601692

Management of hepatic epithelioid haemangio-endothelioma in children: what option? FREE

K Sharif, M English, P Ramani, D Alberti, J-B Otte, P McKiernan, S Gosseye, M Jenney and J de Ville de Goyet

Br J Cancer 90: 1498-1501; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601720

Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study FREE

J Feliu, A Salud, P Escudero, L López-Gómez, C Pericay, C Castañón, M R López de Tejada, J M Rodríguez-García, M P Martínez, M Sanz Martín, J J Sánchez and M González Barón on behalf of the Oncopaz Cooperative Group and Associated Hospitals

Br J Cancer 90: 1502-1507; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601713

Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor FREE

A Sparreboom, D F S Kehrer, R H J Mathijssen, R Xie, M J A de Jonge, P de Bruijn, A S T Planting, F A L M Eskens, C Verheij, G de Heus, A Klaren, S Zhang, T Verhaeghe, P A Palmer and J Verweij

Br J Cancer 90: 1508-1515; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601732

A Phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gall bladder cancer FREE

D C Doval, J S Sekhon, S K Gupta, J Fuloria, V K Shukla, S Gupta and B S Awasthy

Br J Cancer 90: 1516-1520; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601736

High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD) FREE

S Cascinu, M Scartozzi, R Labianca, V Catalano, R R Silva, S Barni, A Zaniboni, A D'Angelo, S Salvagni, G Martignoni, G D Beretta, F Graziano, R Berardi and V Franciosi

Br J Cancer 90: 1521-1525; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601752

Outcome of patients with HIV-related germ cell tumours: a case–control study FREE

T Powles, M Bower, J Shamash, J Stebbing, J Ong, G Daugaard, A De Ruiter, M Johnson, M Fisher, J Anderson, M Nelson, B Gazzard and T Oliver

Br J Cancer 90: 1526-1530; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601762

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Molecular and Cellular Pathology

Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markers FREE

B Weigelt, P Verduijn, A J Bosma, E J Rutgers, H L Peterse and L J van't Veer

Br J Cancer 90: 1531-1537; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601659

Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast FREE

R R Millis, S E Pinder, K Ryder, R Howitt and S R Lakhani

Br J Cancer 90: 1538-1542; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601704

Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients FREE

J A van der Hage, L J C M van den Broek, C Legrand, P C Clahsen, C J A Bosch, E C Robanus-Maandag, C J H van de Velde and M J van de Vijver

Br J Cancer 90: 1543-1550; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601741

200 Sentinel lymph node biopsies without axillary lymph node dissection – no axillary recurrences after a 3-year follow-up FREE

R Reitsamer, F Peintinger, E Prokop, L Rettenbacher and C Menzel

Br J Cancer 90: 1551-1554; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601765

The tumour–stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients FREE

D Masuya, C Huang, D Liu, T Nakashima, K Kameyama, R Haba, M Ueno and H Yokomise

Br J Cancer 90: 1555-1562; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601718

Identification of epidermal growth factor receptor-derived peptides immunogenic for HLA-A2+ cancer patients FREE

H Shomura, S Shichijo, S Matsueda, T Kawakami, Y Sato, S Todo and K Itoh

Br J Cancer 90: 1563-1571; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601728

A population-based study of immunohistochemical detection of p53 alteration in bladder cancer FREE

K T Kelsey, T Hirao, A Schned, S Hirao, T Devi-Ashok, H H Nelson, A Andrew and M R Karagas

Br J Cancer 90: 1572-1576; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601748

Stromal–epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression FREE

L A Dawson, N J Maitland, A J Turner and B A Usmani

Br J Cancer 90: 1577-1582; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601717

A novel immunohistochemical method for estimating cell cycle phase distribution in ovarian serous neoplasms: implications for the histopathological assessment of paraffin-embedded specimens FREE

I S Scott, T M Heath, L S Morris, S M Rushbrook, K Bird, S L Vowler, M J Arends and N Coleman

Br J Cancer 90: 1583-1590; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601660

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Genetics and Genomics

Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas FREE

S Jones, S Lambert, G T Williams, J M Best, J R Sampson and J P Cheadle

Br J Cancer 90: 1591-1593; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601747

Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer FREE

M M Sasiadek, A Stembalska-Kozlowska, R Smigiel, D Ramsey, T Kayademir and N Blin

Br J Cancer 90: 1594-1599; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601679

High-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas FREE

T Takano, A Miyauchi, H Yoshida, K Kuma and N Amino

Br J Cancer 90: 1600-1605; advance online publication, March 9, 2004; doi:10.1038/sj.bjc.6601702

Methylation analysis of the glypican 3 gene in embryonal tumours FREE

G Boily, Z Saikali and D Sinnett

Br J Cancer 90: 1606-1611; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601716

Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses FREE

J Blancato, B Singh, A Liu, D J Liao and R B Dickson

Br J Cancer 90: 1612-1619; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601703

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Experimental Therapeutics

Effects of overexpression of ephrin-B2 on tumour growth in human colorectal cancer FREE

W Liu, Y D Jung, S A Ahmad, M F McCarty, O Stoeltzing, N Reinmuth, F Fan and L M Ellis

Br J Cancer 90: 1620-1626; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601723

Improved biological activity of a mutant endostatin containing a single amino-acid substitution FREE

Y Yokoyama and S Ramakrishnan

Br J Cancer 90: 1627-1635; advance online publication, March 30, 2004; doi:10.1038/sj.bjc.6601745

Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells FREE

R C-F Chan, X-W Pang, Y-D Wang, W-F Chen and Y Xie

Br J Cancer 90: 1636-1643; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601706

alpha-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells FREE

M Tomasetti, M R Rippo, R Alleva, S Moretti, L Andera, J Neuzil and A Procopio

Br J Cancer 90: 1644-1653; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601707

Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats FREE

M Verschraagen, E Boven, E Torun, C A M Erkelens, F H Hausheer and W J F van der Vijgh

Br J Cancer 90: 1654-1659; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601719

Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies FREE

C Perotti, H Fukuda, G DiVenosa, A J MacRobert, A Batlle and A Casas

Br J Cancer 90: 1660-1665; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601722

A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents FREE

A R Parker, C P Leonard, L Hua, R O Francis, S Dhara, A Maitra and J R Eshleman

Br J Cancer 90: 1666-1671; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601740

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice FREE

N Sawada, K Kataoka, K Kondo, H Arimochi, H Fujino, Y Takahashi, T Miyoshi, T Kuwahara, Y Monden and Y Ohnishi

Br J Cancer 90: 1672-1678; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601746

Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2 FREE

J E Nutt, H P Lazarowicz, J K Mellon and J Lunec

Br J Cancer 90: 1679-1685; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601768

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Letters to the Editor

Overdiagnosis of breast cancer in Denmark FREE

P-H Zahl

Br J Cancer 90: 1686; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601738

Reply: Overdiagnosis of breast cancer in Denmark FREE

A H Olsen, A Jensen, S H Njor, E Villadsen, W Schwartz, I Vejborg and E Lynge

Br J Cancer 90: 1687; advance online publication, March 16, 2004; doi:10.1038/sj.bjc.6601739

Cancer care in rural areas FREE

R Colomer, J R Germà, R Rosell and J M Borràs

Br J Cancer 90: 1688; advance online publication, March 23, 2004; doi:10.1038/sj.bjc.6601769

Reply: Cancer care in rural areas FREE

N C Campbell, P A Kiehlmann and L Stevenson

Br J Cancer 90: 1689; advance online publication, April 6, 2004; doi:10.1038/sj.bjc.6601770

The published online date indicates the date that the issue is published online and is the first official publication date of the issue. Each print issue of BJC is published one week after it has been published online.

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