|
|
British Journal of Cancer (2004) 90, 761-769.
doi:10.1038/sj.bjc.6601575
Linking the epigenetic 'language' of covalent histone modifications to cancer
S B Hake1, A Xiao1 and C D Allis1
1Laboratory of Chromatin Biology, The Rockefeller University, Box 78, 1230 York Avenue, New York, NY 10021, USA
Correspondence to: Dr CD Allis, E-mail: alliscd@rockefeller.edu
Received 29 September 2003; accepted 11 November 2003
Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.
Keywords: histones; chromatin; cancer; epigenetics
back to top  |
| Article links | |
| ||
| ||
 | Send to a friend | |
 | Download PDF | |
| ||
| ||
| ||
 | Full text | |
| ||
| ||
| ||
 | Preceding article | |
 | Next article | |
 | Table of Contents | |
| ||
| ||
| ||
| ||
| ||
|
|
|
|
| |||
| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2004 Cancer Research UK | ||
| |||
| Privacy Policy | |||