British Journal of Cancer - Table 4 for article: A phase 1 study of tazarotene in adults with advanced cancer

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A phase 1 study of tazarotene in adults with advanced cancer

P H Jones, R D Burnett, I Fainaru, P Nadolny, P Walker, Z Yu, D Tang-Liu, T S Ganesan, D C Talbot, A L Harris and G J S Rustin

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Table 4. Toxicities at or above grade 2 and their time of onset

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Dose (mg)	Patient no.	Toxicity	Grade	Time of onset (weeks)
1.4	0101	Asthenia	2	4
		Hypercholesterolaemia	2	8
	0103	Hypercholesterolaemia^a	4	1
	0201	Hypercholesterolaemia	2	8
2.1	0105	Asthenia	2	16
		Vomiting	2	16
		Hypercholesterolaemia	2	1
	0206	Asthenia	3	6
		Anorexia	2	4
2.8	0106	Anorexia	2	4
		Abdominal pain	2	4
	0107	Abdominal pain	2	4
		Asthenia	2	4
	0207	Asthenia	2	8
4.2	0208	Asthenia	2	8
	0108	Anorexia	2	8
		Nausea	2	8
		Vomiting	2	8
		Back pain	2	8
8.4		Nil
16.8	0111	Nausea^b	2	2
		Vomiting^b	2	2
	0210	Asthenia	2	2
		Back pain	2	2
		Hypertriglyceridaemia^a	2	2
		Hypercholesterolaemia	3	12
25.2	0115	Dry skin	2	4
		Cheilitis	2	4
		Sore nose	2	4
		Stiff joints	2	8
	0116	Cheilitis	2	4
		Back pain	2	4
		Sore nose	2	8
		Hypertriglyceridaemia	2	2
	0117	Anorexia	2	4
		Cheilitis	2	8
	0214	Asthenia	3	8
		Back pain	3	8
		Myalgia	2	12
33.6^c	0112	Hypercalcaemia	3	4
		Joint stiffness	2	4
	0113	Asthenia	2	4
	0114	Cheilitis	2	2
		Dry skin	2	2
	0211	Headache	2	2
	0212	Myalgia	2	2
	0213	Hypertriglyceridaemia	4	2

^a Grade 2 at baseline. ^bSingle episode, not assessed in the dosage-escalation decision. ^cOnly grade 2 toxicities occurring in the first 4 weeks are listed; numerous other grade 2 toxicities were seen at this dose level (see Table 3).

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TABLE 4

A phase 1 study of tazarotene in adults with advanced cancer

Table 4. Toxicities at or above grade 2 and their time of onset