Molecular and Cellular Pathology
British Journal of Cancer (2003) 89, 860–863. doi:10.1038/sj.bjc.6601201 www.bjcancer.com
Published online 26 August 2003
Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
M L Yager1,2, J A I Hughes1,3, F J Lovicu2, P W Gunning1,3, R P Weinberger1,3 and G M O'Neill1,3
- 1The Oncology Research Unit, The Children's Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW, Australia
- 2Department of Anatomy and Histology, The University of Sydney, Sydney 2000, NSW, Australia
- 3Discipline of Paediatrics and Child Health, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
Correspondence: Dr GM O'Neill, E-mail: GeraldiO@chw.edu.au
Received 20 February 2003; Revised 11 June 2003; Accepted 24 June 2003.
Abstract
Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells.
Keywords:
tropomyosin, actin, neuroblastoma, cytoskeleton
