TABLE 1
FROM:
Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C
P A Whitehouse, S J Mercer, L A Knight, F Di Nicolantonio, A O'Callaghan and I A Cree on behalf of the Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams
BACK TO ARTICLETable 1. Summary of sensitivity data (using an arbitrary threshold of sensitivity defined as a IndexSUM<300 for six concentrations used)
| Drug | No. assessed | No. sensitive | Sensitivity (%) (Index <300) | >95% Inhibition (%) |
|---|---|---|---|---|
| Oesophagogastric cancer | ||||
| Mitomycin C | 21 | 15 | 71 | 14 (three out of 21) |
| Gemcitabine | 17 | 7 | 42 | 6 (one out of 17) |
| Mitomycin C+Gemcitabine | 13 | 13 | 100 | 38 (five out of 13) |
| Colorectal cancer | ||||
| Mitomycin C | 39 | 21 | 54 | 10 (four out of 39) |
| Gemcitabine | 38 | 19 | 50 | 3 (one out of 38) |
| Mitomycin C+gemcitabine | 35 | 35 | 100 | 60 (21 out of 35) |
