British Journal of Cancer

FIGURE 1

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Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C

P A Whitehouse, S J Mercer, L A Knight, F Di Nicolantonio, A O'Callaghan and I A Cree on behalf of the Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams

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Figure 1.

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Summary of the heterogeneity of activity in the ATP-TCA to MMC, gemcitabine, and the combination (GeM) in (A) colorectal cancer (n=39), and (B) oesophagogastric cancer (n=21). The IndexSUM is a parameter describing the concentration–inhibition curve for each drug, or combination in a single number. Using the IndexSUM <300 to indicate sensitivity, GeM is clearly more active than either single agent.

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