British Journal of Cancer

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Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy

P Ricchi, R Zarrilli, A di Palma and A M Acquaviva

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Figure 1.

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Molecular mechanisms that mediate the effects of NSAIDs and anticancer drugs on survival and apoptosis in colon cancer cells. Schematic representation of cytokine, EGF-related growth factors and TRAIL ligand-dependent signal transduction pathways for survival and apoptosis. Stimulatory and inhibitory effects are indicated by arrows and bars, respectively. Abbreviations: MAPK=mitogen-activated protein kinase, MAPKK=mitogen-activated protein kinase kinase, JNK=jun kinase, IkB=inhibitor kinase B, NF-kB=nuclear factor kappa B, COX=cyclooxygenase, PI3K=phosphatidylinositol 3 kinase.

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