Short Communication

British Journal of Cancer (2003) 88, 675–678. doi:10.1038/sj.bjc.6600761 www.bjcancer.com
Published online 4 March 2003

Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

K-M Lee1, J Abel2, Y Ko3, V Harth3, W-Y Park4, J-S Seo4, K-Y Yoo1, J-Y Choi1, A Shin1, S-H Ahn5, D-Y Noh6, A Hirvonen7 and D Kang1

  1. 1Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon-Dong Chongno-Gu, Seoul 110-799, Korea
  2. 2Department of Experimental Toxicology, Research Institute of Environmental Health, Heinrich-Heine-University, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany
  3. 3Department of Internal Medicine, University of Bonn, Wilhelmstreet 35-37, 53111 Bonn, Germany
  4. 4Department of Biochemistry, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799, Korea
  5. 5Department of Surgery, Ulsan University College of Medicine, 388-1 Pungnab-Dong Songpa-Gu, Seoul, Korea
  6. 6Department of Surgery, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799, Korea
  7. 7Finnish Institute of Occupational Health, FIN-00250 Helsinki, Finland

Correspondence: Dr D Kang, E-mail: dhkang@snu.ac.kr

Received 10 September 2002; Revised 18 November 2002; Accepted 20 November 2002.

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Abstract

A case–control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg264Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1–2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu432Val polymorphism appears to play no role here.

Keywords:

CYP19, CYP1B1, alcohol, breast cancer