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British Journal of Cancer (2002) 86, 1078-1080.
doi:10.1038/sj/bjc/6600192
Childhood malignancy and maternal diabetes or other auto-immune disease during pregnancy
L Westbom1, A Åberg2 and B Källén3
1Department of Paediatrics, Lund University Hospital, SE-221 85 Lund, Sweden
2Department of Obstetrics and Gynaecology, Lund University Hospital, SE-221 85 Lund, Sweden
3Tornblad Institute, University of Lund, Biskopsgatan 7, SE-223 62 Lund, Sweden
Correspondence to: Professor B Källén, E-mail: embryol@embryol.lu.se.
Received 2 October 2001; revised 14 December 2001; accepted 21 January 2002
Among 4380 children born in 1987-1997 of women with a diagnosis of diabetes and alive at the age of one, 10 were registered in the Swedish Cancer Registry before the end of 1998. The odds ratio for having a childhood cancer after maternal diabetes, stratified for year of birth, maternal age, parity, multiple birth, and 500 g birth weight class was 2.25 (95%CI 1.22-4.15). Among 5842 children born during the period 1973-1997 whose mothers had other auto-immune diseases (SLE, rheumatoid arthritis, Crohn, ulcerous colitis, multiple sclerosis or thyroiditis), the number of observed childhood cancers (9) was close to that expected (8.5). Maternal diabetes but not other auto-immune diseases may be a risk factor for childhood cancer.
Ó 2002 Cancer Research UK
Keywords: diabetes; childhood cancer; auto-immune disease
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2002 Cancer Research UK | ||
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