FIGURES AND TABLES
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Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breast
N B Teo, B S Shoker, C Jarvis, L Martin, J P Sloane and C Holcombe
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Figure 1.
Simplified diagram of an individual focus of ductal carcinoma in situ (DCIS) and peripheral area where the periductal microvessels were counted.
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Figure 2.
(A) Ductal carcinoma in situ (DCIS) stained immunohistochemically using the CD34 antibody revealing a rim of positive vessels, (B) same area stained for vWF. There is a striking difference in the number of positive cells with the two antibodies in this case.
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Figure 3.
(A) Non-cancerous lobules stained immunohistochemically using the CD34 antibody revealing a rim of positive vessels, (B) same area stained for vWF. There is also a striking difference in the number of positive cells with the two antibodies in this case.
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Figure 4.
Relationship between microvessel density (MVD) and nuclear grade in ductal carcinoma in situ (DCIS) without invasive carcinoma using four types of endothelial markers. The boxes represent the mean values and the whiskers represent 95% confidence interval of the mean. (LNG=low nuclear grade, ING=intermediate nuclear grade, HNG=high nuclear grade).
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Figure 5.
Relationship between microvessel density (MVD) and core area in ductal carcinoma in situ (DCIS) without invasive carcinoma using four types of endothelial markers. (1=vWF, 2=CD31, 3=CD141, 4=CD34).
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Figure 6.
Relationship between microvessel density (MVD) and degree of necrosis in ductal carcinoma in situ (DCIS) with and without invasive carcinoma. The boxes represent the mean values and the whiskers represent 95% confidence interval of the mean. (Degree of necrosis: (1) no necrosis, (2) 1–50% of DCIS focus has necrosis, (3) >50% of DCIS focus has necrosis).
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Figure 7.
Relationship between degree of necrosis and core area in ductal carcinoma in situ (DCIS) with and without invasive carcinoma. The boxes represent the mean values and the whiskers represent 95% confidence interval of the mean. (Degree of necrosis: (1) no necrosis, (2) 1–50% of DCIS focus has necrosis, (3) >50% of DCIS focus has necrosis).
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