Regular Article

British Journal of Cancer (2001) 85, 608–611. doi:10.1054/bjoc.2001.1884 www.bjcancer.com
Published online 14 August 2001

An orthotopic xenograft model of human nonseminomatous germ cell tumour

M L Douglas1, K J Boucaut3, T M Antalis3, C Higgins2, M F Pera4, M A Stuttgen3 and D L Nicol1

  1. 1Department of Surgery, University of Queensland, Brisbane, Queensland, 4102
  2. 2Anatomical Pathology Division, Queensland Health Pathology Service, Princess Alexandra Hospital, Brisbane, Queensland, 4102
  3. 3Cellular Oncology Laboratory, University of Queensland Joint Oncology Program and Queensland Institute of Medical Research, Brisbane, Queensland, 4029
  4. 4Monash Institute of Reproduction and Development, Monash Medical Centre, Clayton, Victoria, 3168, Australia

Received 19 July 2000; Revised 2 April 2001; Accepted 4 April 2001.

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Abstract

We have established the first example of an orthotopic xenograft model of human nonseminomatous germ cell tumour (NSGCT). This reproducible model exhibits many clinically relevant features including metastases to the retroperitoneal lymph nodes and lungs, making it an ideal tool for research into the development and progression of testicular germ cell tumours. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords:

testicular germ cell tumour, NSGCT, metastasis, SCID, orthotopic xenograft

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