Abstract
Oesophageal cancer rates in women in the UK are more than 3 times higher than in most other European populations. A population-based matched case–control study of histologically confirmed squamous cell carcinoma of the oesophagus in women was carried out in 4 regions in England and Scotland. Interviews were carried out in hospital or at home and topics included: smoking; alcohol; tea and coffee consumption; medical and obstetric history; and diet. Response rates were 62% for cases and 65% for first-chosen controls. There were 159 case–control pairs. Significant results were found for: eating salads (odds ratio (OR) 0.42, 95% CI 0.20–0.92 in the highest quartile of consumption) and a light (as distinct from no) breakfast (OR 0.18, 95% CI 0.07 – 0.48) were protective; quantity of tea was a risk factor and there was a significant positive trend with temperature at which hot drinks were consumed (P = 0.03). Alcohol consumption was unrelated to risk, but there was a significant trend with years of smoking (P = 0.015). A protective effect of aspirin consumption was confined to the English centres (OR 0.08, 95% CI 0.01–0.56). Comparison with a parallel study of adenocarcinoma indicated a common protective effect of a healthy diet but otherwise distinct risk factors. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
Boreham R (2000). The Scottish Health Survey 1998: Volume 1: Chapter 8 Smoking, Scottish Executive Health Department
Breslow NE and Day NE (1980) Statistical methods in cancer research. 1, The analysis of case–control studies, IARC Scientific publications, No 32. IARC: Lyon
Brewster DH, Fraser LA, McKinney PA and Black RJ (2000) Socioeconomic status and risk of adenocarcinoma of the oesophagus and cancer of the gastric cardia in Scotland. Brit J Cancer 83: 387–390
Cheng KK and Day NE (1992) Oesophageal cancer in Britain. Brit Med J 304: 711
Cheng KK and Day NE (1996) Nutrition and oesophageal cancer. Cancer Causes Control 7: 33–40
Cheng KK, Sharp L, McKinney PA, Logan RFA, Chilvers CED, Cook-Mozaffari P, Ahmed A and Day NE (2000) The preventability of oesophageal adenocarcinoma in women: a case control study. Brit J Cancer 83: 127–132
Department of Health (1998) Statistics on smoking: England 1976 to 1996. Statistical Bulletin 1998/25, London, Department of Health
de Stefani, Muñoz N, Este-ve J, Vasallo A, Victoria CG and Teuchmann S (1990) Mate drinking, alcohol, tobacco, diet and esophageal cancer in Uruguay. Cancer Res 50: 426–431
Dodaran MS, Silcocks PB and Logan RFA (2001) Continuing rise in incidence of oesophageal adenocarcinoma in England and Wales 1971–1998. Supplement 1 (in press)Gut 48,
Farrow DC, Vaughan TL, Hansten PD, Stanford JL and Risch HA et al (1998) Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomark Prevent 7: 97–102
Langman MJS, Cheng KK, Gilman EA and Lancashire RJ (2000) Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. Brit Med J 320: 1642–1646
Macfarlane GJ and Boyle P (1994) The epidemiology of oesophageal cancer in the UK and other European countries. J Royal Soc Med 87: 334–337
Muñoz N and Day NE (1996) Esophageal Cancer. In Schottenfeld D, Fraumeni JF Jr Cancer Epidemiology and Prevention, Oxford University Press: New York Oxford
Powell J and Allum WH (1992) Oesophageal cancer in Britain. Brit Med J 304: 1380
StataCorp (1999) Stata Statistical Software: Release 6.0. College Station, Texas, Stata Corporation
Victoria CG, Muñoz N, Day NE, Barcelos LB, Peccin DA and Braga NM (1987) Hot beverages and oesophageal cancer in Southern Brazil: a case-control study. Int J Cancer 39: 710–716
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Sharp, L., Chilvers, C., Cheng, K. et al. Risk factors for squamous cell carcinoma of the oesophagus in women: a case–control study. Br J Cancer 85, 1667–1670 (2001). https://doi.org/10.1054/bjoc.2001.2147
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DOI: https://doi.org/10.1054/bjoc.2001.2147
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