Regular Article

British Journal of Cancer (2001) 84, 529–534. doi:10.1054/bjoc.2000.1594 www.bjcancer.com
Published online 13 February 2001

The level of manganese superoxide dismutase content is an independent prognostic factor for glioblastoma. Biological mechanisms and clinical implications

F Ria1, M Landriscina1, F Remiddi1, R Rosselli2, M Iacoangeli2, M Scerrati2, G Pani1, S Borrello1 and T Galeotti1

  1. 1Institute of General Pathology, Catholic University, L. go F. Vito, Rome, 1. I-00168, Italy
  2. 2Institute of Neurosurgery, Catholic University, L. go F. Vito, Rome, 1. I-00168, Italy

Received 27 March 2000; Revised 31 July 2000; Accepted 16 October 2000.

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Abstract

We address the issue of the role of manganese superoxide dismutase in tumorigenesis by studying a relatively homogeneous group of tumours for the correlation between amount of this anti-oxidant enzyme and prognosis. The clinical outcome of 30 patients affected by glioblastomas whose manganese superoxide dismutase content had been established at the time of first diagnosis is compared. When the survival of patients is stratified according to manganese superoxide dismutase level in the tumour, a link of these levels and prognosis can be observed. Patients with high levels of manganese superoxide dismutase show a median survival time of 6.11 months, while patients whose tumours display a low amount of MnSOD have a median survival time of 12.17 months. To assess the upstream mechanisms that sustain the increase in manganese superoxide dismutase content in brain neuroepithelial tumours, we also studied the expression of p53 in a series of 17 astrocytomas of various grading. In all tested astrocytomas, high manganese superoxide dismutase content is associated with cytoplasmic accumulation of p53. Thus glioblastomas can be divided into two distinct groups on the basis of their content of manganese superoxide dismutase, having 'better' or 'worse' prognosis, respectively. The use of this protein as a marker may help to define therapeutic strategies in the clinical management of glioblastoma. © 2001 Cancer Research Campaign

Keywords:

MnSOD, p53, glioblastoma, reactive oxygen species

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