Regular Article

British Journal of Cancer (2000) 83, 1055–1060. doi:10.1054/bjoc.1999.1469 www.bjcancer.com
Published online 19 September 2000

Day–night pattern of energy expenditure and body temperature in cachectic tumour-bearing rats

H Oudart1, A Malan1, Y le Maho1 and A Geloen2

  1. 1Centre d'Ecologie et Physiologie Energétiques, associé à l'Université Louis Pasteur, CNRS, 23 rue Becquerel, Strasbourg F-67087, France
  2. 2Thermorégulation et Energétique de l'Exercice, Université Lyon I, 8 avenue Rockfeller, Lyon, Cedex 08, F-69373, France

Received 14 October 1998; Revised 20 April 1999; Accepted 20 April 1999.

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Abstract

The implication of an increase in energy expenditure in cancer cachexia, which seems to be related to the type of tumour, remains unclear. We therefore investigated the energy metabolism and body temperature in anorectic and cachectic rats bearing the Yoshida sarcoma (TB), in comparison with pair-fed (PF) and ad-libitum fed (AL) control rats. The resting energy expenditure was higher in the TB than in the two control groups when corrected for the modifications of body composition. However, the total energy expenditure did not differ between the TB and the AL, presumably because of the drop of activity in TB. There was a temporal distribution of differences in energy expenditure with higher energy expenditure in TB than in AL during the diurnal phase and a lack of difference during the nocturnal phase. The TB presented a fever, which was limited to the diurnal period. Moreover, the acrophase of the body temperature rhythm was delayed in the TB. These results highlight the circadian effects of tumour development on the energy metabolism of the host and hint to the possible implication of cytokines. © 2000 Harcourt Publishers Ltd © 2000 Cancer Research Campaign

Keywords:

Yoshida sarcoma, energy metabolism, indirect calorimetry, cancer cachexia

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