British Journal of Cancer (2000) 83, 1552–1555. doi:10.1054/bjoc.2000.1476 www.bjcancer.com
Published online 14 November 2000
Lactose and benign ovarian tumours in a case–control study
J A Britton1, C Westhoff2,3, G R Howe3 and M D Gammon4
- 1Division of Environmental Health Science, Mt. Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA
- 2Department of Obstetrics & Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA
- 3Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
- 4Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA
Received 5 April 2000; Revised 2 August 2000; Accepted 3 August 2000.
Top of pageAbstract
We investigated the relation between benign ovarian tumours and lactose among 746 case women identified at seven New York metropolitan hospitals and 404 community controls, age and hospital frequency matched to the expected case distribution. No increase in risk was found for lactose (highest quartile versus lowest: adjusted odds ratio = 0.82 (95% CI 0.57–1.20) or for any other lactose foods. © 2000 Cancer Research Campaign http://www.bjcancer.com
Keywords:
case–control studies, diet, lactose, nutrition, ovarian neoplasms, risk factors
Top of pageReferences
- Bennington JL, Ferguson BR and Haber SL (1968 Incidence and relative frequency of benign and malignant ovarian neoplasms. Obstet Gynecol 32: 627–632
- Britton JA, Westhoff C, Howe GR and Gammon MD (2000 Diet and benign ovarian tumors. Cancer Causes & Control 11: 389–401
- Byers T, Marshall J, Graham S, Mettlin C and Swanson M (1983 A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71: 681–686 | PubMed | ChemPort |
- Conover WJ (1980). Practical Nonparametric Statistics, John Wiley & Sons, Inc.: New York
- Cooper GS, Busby MG and Fairchild AP (1995 Measurement of lactose consumption reliability and comparison of two methods. Ann Edidemiol 5: 473–477
- Cramer DW and Welch WR (1983 Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. J Natl Cancer Inst 71: 717–721 | PubMed | ChemPort |
- Cramer DW, Welch WR, Hutchison GB, Willett W and Scully RE (1984 Dietary animal fat in relation to ovarian cancer risk. Obstet Gynecol 63: 833–838 | PubMed | ISI | ChemPort |
- Cramer DW, Harlow BL, Willett WC, Welch WR, Bell DA, Scully RE, Ng WG and Knapp RC (1989 Galactose consumption and metabolism in relation to the risk of ovarian cancer. Lancet 2: 66–71 | PubMed | ISI | ChemPort |
- Engle A, Muscat JE and Harris RE (1991 Nutritional risk factors and ovarian cancer. Nutr Cancer 15: 239–247 | PubMed | ISI | ChemPort |
- Gardner WU (1961 Tumorigenesis in transplanted irradiated and nonirradiated ovaries. J Natl Cancer Inst 26: 829–853
- Hartge P, Brinton LA, Rosenthal JF, Cahill JI, Hoover RN and Waksberg JS (1984 Random digit dialing in selecting a population-based control group. Am J Epidemiol 120: 825–833
- Herrinton LJ, Weiss NS, Beresford SA, Stanford JL, Wolfla DM, Feng Z and Scott CR (1995 Lactose and galactose intake and metabolism in relation to the risk of epithelial ovarian cancer. Am J Epidemiol 141: 407–416 | PubMed | ISI | ChemPort |
- Hosmer DW and Lemeshow S (1989). Applied Logistic Regression, John Wiley & Sons, Inc.: New York
- Howe GR, Hirohata T, Hislop TG, Iscovich JM, Yuan J-M, Katsouyanni K, Lubin F, Marubini E, Modan D, Rohan T, Toniolo P and Shunzhang Y (1990 Dietary factors and risk of breast cancer: combined analysis of twelve case-control studies. J Natl Cancer Inst 82: 561–569 | Article | PubMed | ChemPort |
- Hunter DJ, Spiegelman D, Adami H, Beeson L, van den Brandt PA, Folsom AR, Fraser GE, Goldbohm A, Graham S, Howe GR, Kushi LH, Marshall JR, McDermott A, Miller AB, Speizer FE, Wolk A, Yaun S and Willett W (1996 Cohort studies of fat intake and the risk of breast cancer – a pooled analysis. N Engl J Med 334: 356–361 | Article | PubMed | ISI | ChemPort |
- Kaufman FR, Kogut MD, Donnell GN, Goebelsmann U, March C and Koch R (1981 Hypergonadotropic hypogonadism in female patients with galactosemia. N Engl J Med 304: 994–998
- Kushi LH, Mink PJ, Folsom AR, Anderson KE, Zheng W, Lazovich D and Sellers TA (1999 Prospective study of diet and ovarian cancer. Am J Epidemiol 149: 21–31 | PubMed | ISI | ChemPort |
- McKay DG (1962 The origins of ovarian tumors. Clin Obstet Gynecol 5: 1181–1197
- Mettlin CJ and Piver MS (1990 A case-control study of milk-drinking and ovarian cancer risk. Am J Epidemiol 132: 871–876 | PubMed | ISI | ChemPort |
- Mink P, Kushi LH, Sellers T, Sheng W and Folsom A (1996 Dietary risk factors for ovarian cancer: A prospective study of older women (Abstract). Am J Epidemiol 143: S59
- Puls LE, Powell DE, DePriest PD, Gallion HH, Hunter JE, Kryscio RJ and van Nagell JR (1992 Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma. Gynecol Oncol 47: 53–57
- Risch HA, Jain M, Marrett LD and Howe GR (1994a Dietary lactose intake, lactose intolerance, and the risk of epithelial ovarian cancer in southern Ontario (Canada). Cancer Causes & Control 5: 540–548
- Risch HA, Jain M, Marrett LD and Howe GR (1994b Dietary fat intake and risk of epithelial ovarian cancer. J Natl Cancer Inst 86: 1409–1415
- Risch HA, Marrett LD, Jain M and Howe GR (1996 Differences in risk factors for epithelial ovarian cancer by histologic type results of a case-control study. Am J Epidemiol 144: 363–372 | PubMed | ISI | ChemPort |
- Russell P and Bannatyne P (1989). Surgical Pathology of the Ovaries, Churchill Livingstone: Edinburgh
- Scrimshaw NS and Murray EB (1988 The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr 48: 1079–1159
- Shu XO, Gao YT, Yuan JM, Ziegler RG and Brinton LA (1989 Dietary factors and epithelial ovarian cancer. Br J Cancer 59: 92–96 | PubMed | ISI | ChemPort |
- Slattery ML, Schuman KL, West DW, French TK and Robison LM (1989 Nutrient intake and ovarian cancer. Am J Epidemiol 130: 497–502
- Tzonou A, Hsieh CC, Polychronopoulou A, Kaprinis G, Toupadaki N, Trichopoulou A, Karakatsani A and Trichopoulos D (1993 Diet and ovarian cancer: a case-control study in Greece. Int J Cancer 55: 411–414 | PubMed |
- Ursin G, Bjelke E, Heuch I and Vollset SE (1990 Milk consumption and cancer incidence: a Norwegian prospective study. Br J Cancer 61: 454–459
- Waksberg JS (1978 Sampling methods for random digit dialing. Journal of the American Statistical Association 73: 40–46
- Webb PM, Bain CJ, Purdie DM, Harvey PW and Green A (1998 Milk consumption, galactose metabolism and ovarian cancer (Australia). Cancer Causes Control 9: 637–644 | Article | PubMed | ISI | ChemPort |
- Westhoff C, Britton JA, Gammon MD, Wright T and Kelsey JL (2000 Oral contraceptives and benign ovarian tumors. Am J Epidemiol 152: 242–246
- Willett W (1990 Nutritional Epidemiology. Oxford University Press, Inc.: New York
- Willett WC, Howe GR and Kushi LH (1997 Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65: 1220S–1228S | PubMed | ChemPort |