Regular Article

British Journal of Cancer (1999) 79, 1302–1303. doi:10.1038/sj.bjc.6690208 www.bjcancer.com
Published online 12 February 1999

Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients

O Díez1, A Osorio2, M Robledo2, A Barroso2, M Domènech1, J Cortés1, J Albertos3, J Sanz4, J Brunet4, J M SanRomán5, M C Alonso4, M Baiget1 and J Benítez2

  1. 1Servei de Genètica, Hospital de Sant Pau, Barcelona, Spain
  2. 2Departamento de Genética, Fundación Jiménez Díaz, Madrid, Spain
  3. 3Servicio de Cirugía, Clínica Rube, Madrid, Spain
  4. 4Servei d'Oncologia Mèdica, Hospital de Sant Pau, Barcelona, Spain
  5. 5Departamento de Cirugía de mama, Fundación Jiménez Díaz, Madrid, Spain

Correspondence: Orland Díez, Servei de Genètica, Hospital de la Santa Creu i Sant Pau, Av. Pare Claret 167, 08025 Barcelona, Spain

Received 27 July 1998; Revised 3 September 1998; Accepted 1 October 1998.

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Abstract

We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) mutation in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185delAG in both Sephardic and Ashkenazi populations.

Keywords:

hereditary breast cancer, Jewish population, Sephardic

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References

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