British Journal of Cancer

FIGURES AND TABLES

FROM:

Age-specific prevalence of HPV genotypes in cervical cytology samples with equivocal or low-grade lesions

S Brismar-Wendel, M Froberg, A Hjerpe, S Andersson and B Johansson

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Figure 1.

Age-specific prevalence of human papillomavirus (HPV) (all types) and HR-HPV infection in women with ASCUS and LSIL. Human papillomavirus all types P(age group times cytological diagnosis)=0.10; LSIL P(age)=0.20, P(age group)=0.03, P(age2)=0.003; ASCUS P(age)=0.001, P(age group)=0.04, P(age2)=0.34; HR-HPV P(age group times cytological diagnosis)=0.15; LSIL P(age)=0.001, P(age group)=0.01, P(age2)=0.19; ASCUS P(age)=0.04, P(age group)=0.11, P(age2)=0.16; all P-values calculated by logistic regression.

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Figure 2.

Age-specific distribution of the HR-HPV genotypes including pHR-HPV68 in all women. The total exceeds 100%, as many women carry more than one HPV genotype.

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Figure 3.

Prevalence of the most common HR-HPV (including pHR-HPV68) genotypes in all LSIL and ASCUS cases.

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Figure 4.

Age-dependent shift in LR vs pHR+HR frequency (% of all HPV infections). LR and pHR+HR P(age2)<0.001 (logistic regression). LR=low-risk HPV, pHR=probable high-risk HPV, and HR=high-risk HPV.

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Figure 5.

Age-specific prevalence of multiple infections. Multiple HPV P(age group)=0.08, P(cytological diagnosis)=0.63, P(age group times cytological diagnosis)=0.73, LSIL P(age2)=0.001, turning point 41.6 years, ASCUS P(age2)=0.76. Multiple HR-HPV P(age group)=0.04, P(cytological diagnosis)=0.71, P(age group times cytological diagnosis)=0.24, LSIL P(age2)=0.04, turning point 38.6 years, ASCUS P(age group)=0.27, P(age2)=0.34. All P-values calculated by logistic regression.

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Figure 6.

Coinfection with HPV16 or HPV18 and clade 3, 5, 7, and 9. Clade 3: HPV61, 72, 81, 83, 84; clade 5: HPV26, 51, 69, 82; clade 7: HPV18, 39, 45, 59, 68, 70; clade 9: HPV16, 31, 33, 35, 52, 58, 67; *clade 7 does not include HPV18 and clade 9 does not include HPV16 in these cross-tabulations.

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Figure 7.

Suggested flowchart for triage HPV testing.

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