Table of contents

Volume 100, Issue 8
Published online 14 April 2009 (1213-1368)

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Minireviews

Methodological approaches in application of synthetic lethality screening towards anticancer therapy

D Canaani

Br J Cancer 100: 1213-1218; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6605000

Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond

R D Riley, W Sauerbrei and D G Altman

Br J Cancer 100: 1219-1229; doi:10.1038/sj.bjc.6604999

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Clinical Studies

Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location

L Guittet, V Bouvier, N Mariotte, J P Vallee, R Levillain, J Tichet and G Launoy

Br J Cancer 100: 1230-1235; advance online publication, March 31, 2009; doi:10.1038/sj.bjc.6604996

Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer

L H Moyes, E F Leitch, R F McKee, J H Anderson, P G Horgan and D C McMillan

Br J Cancer 100: 1236-1239; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6604997

The impact of healthcare costs in the last year of life and in all life years gained on the cost-effectiveness of cancer screening

I M C M de Kok, J J Polder, J D F Habbema, L-M Berkers, W J Meerding, M Rebolj and M van Ballegooijen

Br J Cancer 100: 1240-1244; doi:10.1038/sj.bjc.6605018

A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma

R F Kefford, N P B Thomas, P G Corrie, C Palmer, E Abdi, D Kotasek, J Beith, M Ranson, P Mortimer, A J Watson, G P Margison and M R Middleton

Br J Cancer 100: 1245-1249; advance online publication, March 31, 2009; doi:10.1038/sj.bjc.6605016

O 6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib

A J Watson, M R Middleton, G McGown, M Thorncroft, M Ranson, P Hersey, G McArthur, I D Davis, D Thomson, J Beith, A Haydon, R Kefford, P Lorigan, P Mortimer, A Sabharwal, O Hayward and G P Margison

Br J Cancer 100: 1250-1256; doi:10.1038/sj.bjc.6605015

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Translational Therapeutics

Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

D Yoshikawa, H Ojima, A Kokubu, T Ochiya, S Kasai, S Hirohashi and T Shibata

Br J Cancer 100: 1257-1266; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6604988

Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts

P Cao, S-M Maira, C García-Echeverría and D W Hedley

Br J Cancer 100: 1267-1276; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6604995

The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients

I Van der Auwera, H J Elst, S J Van Laere, H Maes, P Huget, P van Dam, E A Van Marck, P B Vermeulen and L Y Dirix

Br J Cancer 100: 1277-1286; doi:10.1038/sj.bjc.6605013

Intra-tumoural extra-cellular pH: a useful parameter of response to chemotherapy in syngeneic tumour lines

D Lindner and D Raghavan

Br J Cancer 100: 1287-1291; doi:10.1038/sj.bjc.6605022

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Molecular Diagnostics

An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

H A Rogers, S Miller, J Lowe, M-A Brundler, B Coyle and R G Grundy

Br J Cancer 100: 1292-1302; advance online publication, March 17, 2009; doi:10.1038/sj.bjc.6604979

Differential tissue-specific protein markers of vaginal carcinoma

K Hellman, A A Alaiya, S Becker, M Lomnytska, K Schedvins, W Steinberg, A-C Hellström, S Andersson, U Hellman and G Auer

Br J Cancer 100: 1303-1314; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6604975

Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts

K Huhtinen, P Suvitie, J Hiissa, J Junnila, J Huvila, H Kujari, M Setälä, P Härkki, J Jalkanen, J Fraser, J Mäkinen, A Auranen, M Poutanen and A Perheentupa

Br J Cancer 100: 1315-1319; advance online publication, March 31, 2009; doi:10.1038/sj.bjc.6605011

BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers

Y Hirata, N Ogasawara, M Sasaki, T Mizushima, T Shimura, T Mizoshita, Y Mori, E Kubota, T Wada, S Tanida, H Kataoka, T Kamiya, S Higashiyama and T Joh

Br J Cancer 100: 1320-1329; advance online publication, March 31, 2009; doi:10.1038/sj.bjc.6605010

TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy

A Oden-Gangloff, F Di Fiore, F Bibeau, A Lamy, G Bougeard, F Charbonnier, F Blanchard, D Tougeron, M Ychou, F Boissière, F Le Pessot, J-C Sabourin, J-J Tuech, P Michel and T Frebourg

Br J Cancer 100: 1330-1335; doi:10.1038/sj.bjc.6605008

DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure FREE

E Kettunen, M Aavikko, P Nymark, S Ruosaari, H Wikman, E Vanhala, K Salmenkivi, R Pirinen, A Karjalainen, E Kuosma and S Anttila

Br J Cancer 100: 1336-1342; advance online publication, March 31, 2009; doi:10.1038/sj.bjc.6605012

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Genetics and Genomics

Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis

T Pabst, M Eyholzer, J Fos and B U Mueller

Br J Cancer 100: 1343-1346; advance online publication, March 10, 2009; doi:10.1038/sj.bjc.6604977

The BAG-1 cochaperone is a negative regulator of p73-dependent transcription

X-H Wang, D O'Connor, M Brimmell and G Packham

Br J Cancer 100: 1347-1357; advance online publication, March 17, 2009; doi:10.1038/sj.bjc.6604985

Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival

K Einarsdóttir, H Darabi, K Czene, Y Li, Y L Low, Y Q Li, C Bonnard, S Wedrén, E T Liu, P Hall, J Liu and K Humphreys

Br J Cancer 100: 1358-1364; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6604984

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Letters to the Editor

CD133 expression in different stages of gastric adenocarcinoma

M Boegl and C Prinz

Br J Cancer 100: 1365-1366; doi:10.1038/sj.bjc.6605001

Reply: CD133 expression in different stages of gastric adenocarcinoma

L M Smith, A Nesterova, M C Ryan, S Duniho, M Jonas, M Anderson, M K Sutherland, K L Van Orden, P A Moore, S M Ruben and P J Carter

Br J Cancer 100: 1367; advance online publication, March 24, 2009; doi:10.1038/sj.bjc.6605002

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Corrigendum

Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy FREE

L Paré, E Marcuello, A Altés, E del Río, L Sedano, J Salazar, A Cortés, A Barnadas and M Baiget

Br J Cancer 100: 1368; doi:10.1038/sj.bjc.6605004

The published online date indicates the date that the issue is published online and is the first official publication date of the issue. Each print issue of BJC is published one week after it has been published online.

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