Clinical Study

BJC Open article

British Journal of Cancer (2009) 100, 436–441. doi:10.1038/sj.bjc.6604863 www.bjcancer.com
Published online 3 February 2009

The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: a systematic review and meta-analysis

A Wailoo1, A Sutton2 and A Morgan3

  1. 1Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, UK
  2. 2Department of Health Sciences, University of Leicester, Leicester, UK
  3. 3Health Services Research, Sheffield, UK

Correspondence: Dr A Wailoo, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK. E-mail: a.j.wailoo@sheffield.ac.uk

Received 14 August 2008; Revised 3 November 2008; Accepted 4 December 2008

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Abstract

We aimed to assess the incidence of febrile neutropenia in patients with non small cell lung cancer treated with docetaxel as second line chemotherapy by systematic review and meta-analysis of clinical studies. Published studies were retrieved and included if they considered docetaxel at the licensed dose after a previous chemotherapy regimen, and reported the proportion of patients getting FN. Meta-analysis was conducted to estimate the proportion of patients who experience one or more episodes of FN. The pooled, random effects meta-analysis estimate for the proportion of patients who experience one or more episodes of FN on docetaxel was 5.95% (95% CI 4.22–8.31) based on 13 studies, comprising 1609 patients. No significant differences were seen either between studies that permitted the use of prophylactic granulocyte colony-stimulating factors or between phase II and phase III trials.

Evidence from randomised controlled trials suggests that the incidence of FN with docetaxel is around 6% and therefore an important factor to consider in the choice of the chemotherapy regimen.

Keywords:

febrile neutropenia; docetaxel; meta-analysis; systematic review

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