Clinical significance of MiRNA expression

Tumour MiRNAs - the focus of these articles is on changes during treatment, detection in urine or detection in tumours and how they relate to outcome and prognosis in a wide range of tumour types - pancreatic, prostate, bladder, colon cancer, melanoma, multiple myeloma and peripheral nerve sheath tumours. Though there is a major focus on genetic changes and the targeting of cancer treatment, microRNAs are another significant epigenetic mechanism for regulation in tumour biology that needs to integrated with the genetic profiles.

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Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma  Open

C I Jones, M V Zabolotskaya, A J King, H J S Stewart, G A Horne, T J Chevassut and S F Newbury

British Journal of Cancer 107: 1987-1996; Published online, 20 November 2012; doi:10.1038/bjc.2012.525

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Clinical significance of miR-144-ZFX axis in disseminated tumour cells in bone marrow in gastric cancer cases  Open

S Akiyoshi, T Fukagawa, H Ueo, M Ishibashi, Y Takahashi, M Fabbri, M Sasako, Y Maehara, K Mimori and M Mori

British Journal of Cancer 107: 1345-1353; Published online, 06 September 2012; doi:10.1038/bjc.2012.326

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MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer  Open

S Ali, H Saleh, S Sethi, F H Sarkar and P A Philip

British Journal of Cancer 107: 1354-1360; Published online, 28 August 2012; doi:10.1038/bjc.2012.383

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The prognostic importance of miR-21 in stage II colon cancer: a population-based study  Open

S Kjaer-Frifeldt, T F Hansen, B S Nielsen, S Joergensen, J Lindebjerg, F B Soerensen, R dePont Christensen and A Jakobsen

British Journal of Cancer 107: 1169-1174; Published online, 25 September 2012; doi:10.1038/bjc.2012.365

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Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation  Open

J S Hall, J Taylor, H R Valentine, J J Irlam, A Eustace, P J Hoskin, C J Miller and C M L West

British Journal of Cancer 107: 684-694; Published online, 17 July 2012; doi:10.1038/bjc.2012.294

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An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer  Open

S Miah, E Dudziec, R M Drayton, A R Zlotta, S L Morgan, D J Rosario, F C Hamdy and J W F Catto

British Journal of Cancer 107: 123-128; Published online, 29 May 2012; doi:10.1038/bjc.2012.221

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The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer  Open

C B Lajer, E Garnæs, L Friis-Hansen, B Norrild, M H Therkildsen, M Glud, M Rossing, H Lajer, D Svane, L Skotte, L Specht, C Buchwald and F C Nielsen

British Journal of Cancer 106: 1526-1534; Published online, 03 April 2012; doi:10.1038/bjc.2012.109

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High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer  Open

R Hamano, H Miyata, M Yamasaki, K Sugimura, K Tanaka, Y Kurokawa, K Nakajima, S Takiguchi, Y Fujiwara, M Mori and Y Doki

British Journal of Cancer 106: 1415-1423; Published online, 20 March 2012; doi:10.1038/bjc.2012.90

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miR-205 negatively regulates the androgen receptor and is associated with adverse outcome of prostate cancer patients  Open

Z Hagman, B S Haflidadóttir, J A Ceder, O Larne, A Bjartell, H Lilja, A Edsjö and Y Ceder

British Journal of Cancer 108: 1668-1676; Published online, 09 April 2013; doi:10.1038/bjc.2013.131

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Changes in circulating microRNA levels associated with prostate cancer  FREE

R J Bryant, T Pawlowski, J W F Catto, G Marsden, R L Vessella, B Rhees, C Kuslich, T Visakorpi and F C Hamdy

British Journal of Cancer 106: 768-774; Published online, 12 January 2012; doi:10.1038/bjc.2011.595

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Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma  FREE

H Konishi, D Ichikawa, S Komatsu, A Shiozaki, M Tsujiura, H Takeshita, R Morimura, H Nagata, T Arita, T Kawaguchi, S Hirashima, H Fujiwara, K Okamoto and E Otsuji

British Journal of Cancer 106: 740-747; Published online, 19 January 2012; doi:10.1038/bjc.2011.588

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Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors  FREE

Y Xu, T Brenn, E R S Brown, V Doherty and D W Melton

British Journal of Cancer 106: 553-561; Published online, 05 January 2012; doi:10.1038/bjc.2011.568

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MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression  Open

N Presneau, M Eskandarpour, T Shemais, S Henderson, D Halai, R Tirabosco and A M Flanagan

British Journal of Cancer 108: 964-972; Published online, 22 November 2012; doi:10.1038/bjc.2012.518

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Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer  Open

T Kawaguchi, S Komatsu, D Ichikawa, R Morimura, M Tsujiura, H Konishi, H Takeshita, H Nagata, T Arita, S Hirajima, A Shiozaki, H Ikoma, K Okamoto, T Ochiai, H Taniguchi and E Otsuji

British Journal of Cancer 108: 361-369; Published online, 17 January 2013; doi:10.1038/bjc.2012.546