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Metabolic perturbations are a hallmark of cancer. Unique bioenergetic and biosynthetic alterations enable growth and metastasis in a nutrient-poor environment and understanding these modified pathways has been a key focus of research so far. We are now at a position where we need to develop these findings into preclinical and clinical outcomes, and this Special Issue on Cancer Metabolism highlights the ongoing challenges in the field. Curated by Professor Adrian Harris (University of Oxford) and Dr Christian Frezza (University of Cambridge), the Special Issue contains a selection of articles and commissioned content that provide insights into a variety of ongoing questions in oncometabolism, to help drive the translation of these findings towards the clinic.